基于石墨烯相关材料在外周神经损伤修复中的应用

Application of graphene-based materials in peripheral nerve injury repair

外周神经损伤(PNI)后会严重影响患者的生活质量, 外周神经损伤后机体有一定的再生能力但修复速度很慢且功能恢复不充分, 这是外周神经损伤后亟待解决的问题。有效的手术和康复策略以及新技术的开发是我们的研究方向。外周神经损伤后的修复主要从三个方面进行分析。第一是改善轴突的内在生长能力, 这个过程涉及信号传递和各种神经调节因子的正负调节。其次是改善损伤修复环境, 其中施万细胞和巨噬细胞发挥各自的作用改善抑制性环境。最后是修复后的神经与被支配组织的成功连接。人们一直在尝试开发基于生物材料的治疗外周神经损伤的方法, 以再生功能失调的神经组织。石墨烯是目前已知的最薄、最强、最轻的材料, 具有良好的导热性和导电性, 石墨烯基材料(GBMs)用于神经损伤被认为是一种新兴技术, 为外周神经损伤修复带来了希望。

Peripheral nerve injury(PNI)can seriously affect the quality of life of patients.The body has a cer-tain regenerative capacity after peripheral nerve injury but the repair rate is slow and the functional recovery is inade-quate,which is an urgent problem after peripheral nerve injury.Effective surgical and rehabilitation strategies as well as the development of new technologies are the direction of our research.Repair after peripheral nerve injury is ana-lyzed in three main aspects.The first is to improve the intrinsic growth capacity of axons,a process that involves signa-ling and the positive and negative regulation of various neuromodulators.The second is the improvement of the injury repair environment,in which Schwann cells and macrophages play their respective roles to improve the inhibitory envi-ronment.Finally,there is the successful connection of the repaired nerve to the innervated tissue.There have been at-tempts to develop biomaterial-based treatments for peripheral nerve injury to regenerate dysfunctional nerve tissue.Gra-phene is the thinnest,strongest,and lightest material known,with good thermal and electrical conductivity.The gra-phene-based materials for nerve injury are considered an emerging technology that holds promise for peripheral nerve injury repair.