肠道菌群与早产儿脑发育及神经认知行为关系的研究

Research advances on the correlation of gut microbiota with brain development and neurocognitive behavior in preterm infants

肠道菌群是生命各个阶段健康和疾病的重要决定因素。了解肠道菌群如何塑造婴幼儿大脑结构、功能并影响神经认知行为发育是当前重要的研究前沿。作为特殊婴幼儿群体,早产儿面临脑发育异常及不良神经行为发育的风险较高。本文总结早产儿肠道菌群定植特点,探讨肠道菌群与大脑发育和神经认知行为的潜在关联,为优化早产儿神经行为发育结局,制定相关干预策略提供理论支撑。

Gut microbiota is an important determinant of health and disease at all stages of life.Understanding how gut microbiota shapes infant brain structure,function and neurocognitive behavior in infants is an important current research frontier.Premature infants are a special group of infants with a high risk of abnormal brain development and poor neurobehavioral development.This paper aims to summarize the characteristics of gut microbiota colonization in preterm infants and explore the potential associations of gut microbiota with brain development and neurocognitive behavior,so as to provide theoretical evidence for optimizing neurodevelopmental outcomes and making intervention strategies in preterm infants.