柴胡舒胰颗粒联合经内镜逆行胰胆管造影治疗慢性胰腺炎的临床疗效及对患者生活质量的影响研究

Clinical efficacy of Chaihu Shuyi granule combined with endoscopic retrograde cholangiopancreatography in the treatment of chronic pancreatitis and its influence on the quality of life of patients

目的探讨柴胡舒胰颗粒联合经内镜逆行胰胆管造影(ERCP)治疗慢性胰腺炎的临床疗效,及对患者症状、生活质量改善的影响。方法纳入2019年10月—2022年7月收治的64例慢性胰腺炎患者,采用随机对照试验方法,分为对照组和试验组,每组各32例。对照组接受ERCP及内科基础治疗,试验组在对照组基础上联合中药复方柴胡舒胰颗粒治疗,12周为1个疗程。观察2组治疗前后M-ANNHEIM临床特征评分、临床症状评分、生活质量评分及不良反应情况。结果2组治疗后M-ANNHEIM评分均较治疗前显著下降(P<0.05)。试验组的临床总有效率(90.6%)显著高于对照组(53.1%)(P<0.05)。2组治疗后腹痛、腹胀、恶心呕吐、纳差、乏力症状评分较治疗前显著下降(P<0.05);且试验组治疗后腹痛、恶心呕吐、便秘、乏力症状评分显著低于对照组(P<0.05)。2组治疗后生活质量评分均较治疗前显著改善(P<0.05);且试验组治疗后生活质量显著优于对照组(P<0.05)。治疗期间,2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论柴胡舒胰颗粒联合ERCP治疗慢性胰腺炎能显著提高临床疗效,有效缓解症状并改善生活质量。

Objective The clinical efficacy of Chaihu Shuyi granules combined with endoscopic retrograde cholangiopancreatography(ERCP)in the treatment of chronic pancreatitis was explored,as well as the effect on the improvement of symptoms and quality of life in patients.Methods From October 2019 to July 2022,64 patients with chronic pancreatitis were enrolled in the study.A randomized controlled trial was conducted to divide the patients into control and experimental group.The control group only received ERCP and basic medical treatment,and the experimental group was additionally treated with Chaihu Shuyi granules,with 32 cases in each group and 12 weeks as a course.Before and after treatment for patients in the two groups,the M-ANNHEIM severity score,clinical symptom score,quality of life score,and the occurrence of adverse events were observed.Results M-ANNHEIM severity score in both groups decreased significantly after treatment compared with before treatment(P<0.05).The total clinical efficacy in experimental group(90.6%)was significantly higher than that of control group(53.1%)(P<0.05).The symptom scores of abdominal pain,abdominal distension,nausea or vomiting,poor appetite,and fatigue in both groups after treatment was significantly decreased than those before treatment(P<0.05).The post-treatment scores of abdominal pain,nausea or vomiting,constipation,and fatigue symptoms in the experimental group decreased more significantly than those of the control group(P<0.05).Quality of life scores in both groups improved after treatment(P<0.05);The improvement in quality of life in the experimental group was more obvious than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups during the treatment(P>0.05).Conclusion Chaihu Shuyi granule combined with ERCP can improve clinical efficacy significantly,relieve symptoms and improve quality of life as well.