中国肝硬化临床诊治共识意见

Chinese consensus on clinical diagnosis and therapy of liver cirrhosis

肝硬化是由多种病因引起的以弥漫性肝细胞坏死、肝细胞异常再生、血管新生、纤维组织大量增生和假小叶形成为组织学特征的进行性慢性肝病。肝硬化以肝功能减退和门静脉高压为特征性表现,晚期可出现多种并发症。为规范肝硬化的诊治,以指导临床实践,中华医学会消化病学分会组织国内相关领域专家,参考国内外最新指南和共识意见,总结近年来相关研究成果,就肝硬化的病因、病理和发病机制、临床表现、主要并发症、诊断、治疗,以及预后和慢病管理等方面形成共识。本共识意见包含了43项陈述条款。由于肝硬化相关并发症已有多个指南和共识意见发表,本共识重点围绕肝硬化本身的研究进展进行叙述。

Liver cirrhosis,characterized by diffuse hepatocytes necrosis,insufficient regeneration of hepatocytes,angiogenesis,severe fibrosis and the formation of pseudolobules,is a progressive chronic hepatic disease induced by a variety of causes.It is clinically characterized by liver function damage and portal hypertension,and many complications may occur in the late stage.Based on the update relevant guidelines,experts′consensuses,and research advances on the diagnosis and treatment of cirrhosis,Chinese Society of Gastroenterology of Chinese Medical Association established a consensus aiming to standardize the clinical diagnosis and treatment of liver cirrhosis and guide clinical practice.This consensus contains 43 statements on the etiology,pathology and pathogenesis,clinical manifestations,major complications,diagnosis,treatment,prognosis and chronic disease management of liver cirrhosis.Since several guidelines and experts′consensuses on the complications of liver cirrhosis have been published,this consensus focuses on the research progress of liver cirrhosis itself.