儿童造血干细胞移植致性腺损伤研究进展

Advances in gonadal damage in children induced by hematopoietic stem cell transplantation

造血干细胞移植(hematopoietic stem cell transplantation,HSCT)是一种重建正常造血和免疫功能的技术,目前已成为儿童多种恶性及非恶性疾病的治疗方案。随着医学技术的发展,患儿HSCT术后长期生存率显著提高,同时对HSCT后期效应的关注和认识也在不断提高。性腺损伤是儿童HSCT术后发病率最高的内分泌并发症之一,表现为性激素分泌失调、青春期发育异常和成年不孕不育,严重影响患儿的心理健康和生活质量。因此,理解儿童HSCT致性腺损伤的潜在机制,评估危险因素,筛选性腺功能受累的预警及功能恢复标志物,采取相应的干预和保护措施,将有助于减轻患儿及家庭的心理及经济负担。

Hematopoietic stem cell transplantation(HSCT),as a technique to reconstruct normal hematopoietic and immune function,has become a treatment option for a variety of malignant and non-malignant diseases in children.With the development of medical technology,the long-term survival rate of children after HSCT is significantly improved.At the same time,there is more concern and awareness about the late effects of HSCT.As one of the endocrine complications with the highest incidence in children after HSCT,gonadal damage leads to sex hormone secretion disorder,adolescent dysplasia,and infertility in adulthood,which has a serious influence on children′s mental health and quality of life.Therefore,it is helpful to reduce the psychological and economic burden on children and their families by understanding its potential mechanism,evaluating risk factors,screening early warning and recovery markers of gonadal function as well as taking corresponding preventive and protective measures.