拟除虫菊酯暴露对儿童发育影响的研究进展

Advances in the effects of pyrethroid exposure on child development

拟除虫菊酯是日常生活中应用广泛的一类合成有机杀虫剂,在水环境中具有高毒性,可导致生物出现神经中毒症状。近年来,环境暴露成为儿童生长发育过程中重要因素之一。拟除虫菊酯在环境中的暴露逐渐增加,使其对儿童生长发育的影响也备受重视。国内外学者通过大量的研究发现拟除虫菊酯对多系统发育产生影响:妊娠期暴露可导致胎儿宫内生长发育受限、畸形等,出生后暴露可导致认知发育迟缓、青春期发育异常,也可能增加罹患过敏性疾病、喘息、咳嗽、急性淋巴细胞白血病的风险。该文就拟除虫菊酯暴露对儿童生长发育过程的影响进行综述。

Pyrethroids,a broad class of synthetic organic insecticides applied in daily life,are highly toxic in the water environment and can cause organisms to develop symptoms of neurotoxicity.Environmental exposure has become one of the important factors explored during child growth and development in recent years,and the exposure of pyrethroids in the environment has gradually increased,making their effects on child growth and development also highly valued.A large number of studies at home and abroad have found that pyrethroids have effects on multi system development:exposure during pregnancy can lead to intrauterine growth restriction,malformations,etc.Postnatal exposure can lead to cognitive retardation,abnormal pubertal development,and may also increase the risk of allergic diseases,wheeze,cough,and acute lymphoblastic leukemia.This article provides a review of the effects of pyrethroid exposure on growth and developmental processes in children.