右美复合罗哌卡因应用于分娩镇痛研究进展

Research progress of dexmedetomidine combined with ropivacaine in labor analgesia

分娩痛是存在于分娩过程中自然的生理反应且伴随着不可避免的剧痛。如何减轻分娩疼痛的程度一直是现代麻醉医学发展中需要重点关注的问题之一,分娩镇痛用药则作为重中之重被关注。椎管内麻醉一直是分娩镇痛首选方式,用药多以局部麻醉药为主,其中罗哌卡因因其独特的药理学特点而列为首选用药,右美托咪定则常为辅助硬膜外分娩镇痛用药。近年大量研究表明,右美托咪定复合罗哌卡效果较单纯罗哌卡因分娩镇痛效果更佳,但其机制仍需进一步研究探索。

Labor pain is a natural physiological reaction that exists in the process of childbirth and is inevitably ac-companied by severe pain.How to reduce the degree of labor pain has always been a crucial issue in the development of mod-ern anesthesia medicine.Intrathecal anesthesia has always been the preferred method for labor analgesia,and the major drug use is local anesthesia,among which ropivacaine is listed as the preferred drug due to its characteristic pharmacological char-acteristics,and dexmedetomidine is a drug with synergistic epidural delivery analgesic onset.A large number of studies in recent years have shown that dexmedetomidine combined with ropivacaine is more effective than ropivacaine alone in deliv-ering analgesia,but the mechanism still needs further research to explore.