临床药师参与5例海分枝杆菌感染患者治疗的回顾性分析

Retrospective analysis of clinical pharmacists participated in the treatment of 5 patients with Mycobacterium marinum infection

目的:探讨海分枝杆菌感染的诊断和治疗,为临床提供参考。方法:查阅2016年1月至2021年12月间临床药师会诊病例中诊断为海分枝杆菌感染患者的病例资料,考察患者暴露史、受伤部位、确诊时间、治疗方案及药物不良反应发生情况等。结果:5例海分枝杆菌感染患者中均有海鲜或海鲜环境暴露史,所有患者受伤部位均为手,其中3例为Ⅱ型感染、2例为Ⅲ型感染。确诊时间29~368 d,疗程121~249 d。4例采用2种药物联合治疗方案、1例采用3药联合治疗方案,5名患者均改善,无1例患者发生严重药物不良反应。结论:临床药师与临床医生合作可缩短确诊时间,促进安全、合理用药。

OBJECTIVE To discuss the diagnosis and treatment of Mycobacterium marinum infection in order to provide clinical reference.METHODS Refer to the case data of patients diagnosed as Mycobacterium marinum infection in the clinical pharmacist consultation cases from January 2016 to December 2021,and investigate the patient's exposure history,injury site,diagnosis time,treatment plan and adverse drug reactions etc.RESULTS Five patients with Mycobacterium marinum infection had a history of exposure to seafood or seafood environment.The injured parts of all patients were hands,of which three were type Ⅱ infection and two were type Ⅲ infection.The diagnosis time was 29-368 days,and the course of treatment was 121-249 days.Four patients were treated with two drugs and one with three drugs.All five patients were cured,and none of the patients had serious adverse drug reactions.CONCLUSION The cooperation between clinical pharmacists and clinicians can shorten the time of diagnosis and promote safe and rational use of drugs.