影响文拉法辛血药浓度相关因素的研究进展

Research progress of the influencing factors for blood concentration of vanlafaxine

文拉法辛为苯乙胺类抗抑郁药,具有抗抑郁谱广、药物起效快、生物利用度高、安全耐受性高、对5-HT选择吸收抑制效果好等优点,在治疗重度抑郁、广泛性焦虑障碍和抑郁共病方面占有重要地位,但该药药动学过程个体差异较大,且其血药浓度受患者个体、药物相互作用和基因多态性等多方面因素影响,导致治疗效果不理想或治疗无效。该文通过检索PubMed、Medline、Embase、CENTRAL、PsycNET、中国生物医学文献数据库、CNKI、维普、万方等数据库,搜索建库至2022年12月文拉法辛治疗药物监测的相关文献,旨在对影响文拉法辛血药浓度的因素进行综述,为该药在临床应用中的安全、有效提供参考。

Venlafaxine is an anilenediamine antidepressant with a wide antidepressant spectrum,fast drug onset,high bioavailability,high safety tolerance,and better absorption inhibition of 5-HT selection compared to other traditional antidepressants.It plays an important role in the treatment of severe depression,generalized anxiety disorder and depression comorbidity,but the pharmacokinetic process is greatly different,and its blood concentration is affected by various factors such as the patient itself,drug interaction and gene polymorphisms,resulting in unsatisfactory treatment effect or ineffective treatment.This paper aims to review the factors affecting blood concentration of vanafaxine by searching PubMed,Medline,Embase,CENTRAL,PsycNET,Chinese biomedical literature database,CNKI,VIP,Wanfang until December 2022 to provide a reference for the safe and effective use of the drug in clinical application.