肥胖成人慢性腹泻患病率的系统评价和Meta分析

The prevalence of chronic diarrhea in obese adults:a systematic review with meta-analysis

目的肥胖已成为全球严重的健康问题。多项研究表明,慢性腹泻在肥胖人群中较为常见。本研究对肥胖成人中慢性腹泻的患病率进行了系统评价和Meta分析。方法在PubMed、Embase和Web of Science文献数据库进行了系统检索,检索时间截止至2022年10月15日。本研究纳入了能够计算腹泻患病率的基于人群或肥胖患者的研究,由2名研究人员独立进行研究筛选,数据提取和质量评估。数据采用随机效应模型进行汇总。结果本研究共评估了8项研究,涉及19701名受访者,其中11820名为超重和肥胖个体。身体质量指数(body mass index,BMI)≥25 kg/m^(2)的超重肥胖人群中,慢性腹泻的总体患病率为23.02%(95%CI:17.47%,28.57%)。肥胖组(BMI≥30 kg/m^(2))的腹泻患病率(23.79%,95%CI:16.29%,31.29%)高于超重组(25 kg/m^(2)≤BMI<30 kg/m^(2),18.82%,95%CI:13.02%,24.62%),但差异不具有统计学意义(P=0.30)。结论慢性腹泻在肥胖人群中相当常见,随着肥胖人数的增加,肥胖与慢性腹泻的共存值得更多关注。

Objective Obesity has become a serious global health concern.A number of studies suggest that chronic diarrhea is frequent in obese people.We performed a systematic review and meta-analysis to assess the prevalence of chronic diarrhea in obese adults.Methods We systematically searched PubMed,Embase,and Web of Science for studies from inception through October 15,2022.We included population-based or obese patient-based studies that could calculate the prevalence of diarrhea.Two researchers independently determined study eligibility,extracted data,and assessed quality.Data were pooled using a random effects model.Results Overall,8 studies with 19,701 respondents were assessed,including 11,820 overweight and obese individuals.The pooled chronic diarrhea rate was 23.02%(95%CI:17.47%,28.57%)in people with a BMI≥25 kg/m^(2).The prevalence of diarrhea in the obese group(23.79%,95%CI:16.29%,31.29%)was higher than that in the overweight group(18.82%,95%CI:13.02%,24.62%),but it was not statistically significant(P=0.30).Conclusions Chronic diarrhea is quite common in obese populations.With the increasing number of obese people,and the coexistence of obesity and chronic diarrhea deserves extra attention.