腹腔加压气溶胶化疗治疗结直肠癌腹膜转移研究进展

Research progress in pressurized intraperitoneal aerosol chemotherapy for colorectal cancer peritoneal metastases

腹膜转移是结直肠癌的常见转移方式,即使进行积极治疗,结直肠癌腹膜转移患者的预后仍较差。近年来,腹腔加压气溶胶化疗(pressurized intraperitoneal aerosol chemotherapy,PIPAC)作为一种新的腹腔内化疗方式受到了广泛关注,全球多个国家的研究者开展了大量与PIPAC相关的前瞻性研究和临床试验,对于腹膜癌患者来说,PIPAC已成为一种安全有效的且有前景的治疗方式,多个医疗中心已经将其用于治疗腹膜癌患者。随着PIPAC相关的临床证据越来越多,其在临床中的应用越发受到重视。本文就PIPAC治疗结直肠癌腹膜转移的理论基础、发展历程、操作流程、适应证、禁忌证、药物方案和临床应用的最新进展进行综述,以期为临床实践和研究提供参考。

Peritoneal metastasis(PM)is a common form of metastasis of colorectal cancer,and the prognosis of patients with colorectal cancer peritoneal metastases is poor despite active treatment.In recent years,a new method of intraperitoneal chemotherapy-pressurized intraperitoneal aerosol chemotherapy(PIPAC)–has received widespread attention.Researchers in multiple countries have carried out many prospective studies and clinical trials based on the belief that PIPAC is a safe,effective,and promising treatment for patients with peritoneal cancer.PIPAC has also been used by several medical centers to treat patients with peritoneal cancer.With the increasing clinical evidence for PIPAC,researchers are paying more attention to its clinical applications.Here,the theoretical basis,development history,operation procedure,indications,contraindications,and drug regimen for PIPAC,as well as the latest progress in its clinical application in the treatment of colorectal cancer peritoneal metastases are reviewed.This review aims to provide a reference for clinical practice and research.