成年人收缩压与尿酸、血脂、血糖的关联研究

Correlations of systolic blood pressure with uric acid,blood lipid and blood glucose

目的分析成年人收缩压(SBP)水平与尿酸(UA)、血脂、血糖的关联,为血压管理和心血管疾病早期预防提供依据。方法基于中国健康与营养调查(CHNS)项目,收集2004年和2009年接受调查的研究对象资料,主要包括人口学信息、血压、UA、血脂和血糖等。根据2004年和2009年测量的SBP分为4组:SBP均<140 mmHg为持续正常组;2004年≥140 mmHg、2009年<140 mmHg为降低组;2004年<140 mmHg、2009年≥140 mmHg为升高组;SBP均≥140 mmHg为持续偏高组;采用多因素logistic回归模型分析SBP与UA、血脂、血糖的关联。结果纳入5086人资料,其中男性2374人,占46.67%;女性2712人,占53.33%。年龄为(48.0±7.2)岁。持续正常组、降低组、升高组和持续偏高组SBP的M(QR)分别为117.00(13.33)、146.67(15.33)、122.67(12.00)和150.67(18.66)mmHg。多因素logistic回归分析结果显示,调整性别、年龄和婚姻状况等因素,与持续正常组相比,降低组与空腹血糖异常存在统计学关联(OR=1.383,95%CI:1.008~1.896);升高组与UA异常(OR=1.495,95%CI:1.195~1.869)、低密度脂蛋白胆固醇异常(OR=1.226,95%CI:1.030~1.460)、三酰甘油异常(OR=1.446,95%CI:1.203~1.739)、总胆固醇异常(OR=1.261,95%CI:1.057~1.504)存在统计学关联;持续偏高组与UA异常(OR=1.603,95%CI:1.188~2.164)、三酰甘油异常(OR=1.619,95%CI:1.253~2.093)、空腹血糖异常(OR=1.565,95%CI:1.166~2.100)存在统计学关联。结论成年人SBP升高与UA异常、血脂异常及血糖异常存在统计学关联。

Objective To analyze the correlations of systolic blood pressure(SBP)with uric acid,blood lipid and blood glucose in adults,so as to provide the evidence for blood pressure management and early prevention of cardiovascular diseases.Methods Based on the China Health and Nutrition Survey,data of participants in 2004 and 2009 was collect⁃ed,including demographic characteristics,blood pressure,uric acid,blood lipid and blood glucose.Participants with SBP<140 mmHg both in 2004 and 2009 were divided into the continuously normal group,participants with SBP≥140 mmHg in 2004 and<140 mmHg in 2009 were divided into the reduced group,participants with SBP<140 mmHg in 2004 and≥140 mmHg in 2009 were divided into the elevated group,and participants with SBP≥140 mmHg both in 2004 and 2009 were divided into the continuously high group.Multivariable logistic regression model was used to ana⁃lyze the correlations of SBP with uric acid,blood lipid and blood glucose.Results A total of 5086 subjects were in⁃cluded in this study with a mean age of(48.0±7.2)years,including 2374 males(46.67%)and 2712 women(53.33%).The median(interquartile range)of SBP was 117.00(13.33)mmHg in the continuously normal group,146.67(15.33)mmHg in the reduced group,122.67(12.00)mmHg in the elevated group and 150.67(18.66)mmHg in the continuous⁃ly high group.Multivariable logistic regression analysis showed that compared with the continuously normal group,the reduced group was correlated with abnormal fasting blood glucose(OR=1.383,95%CI:1.008-1.896);the elevated group was correlated with abnormal uric acid(OR=1.495,95%CI:1.195-1.869),abnormal low density lipoprotein cholesterol(OR=1.226,95%CI:1.030-1.460),abnormal triglyceride(OR=1.446,95%CI:1.203-1.739)and abnormal total cholesterol(OR=1.261,95%CI:1.057-1.504);the continuously high group was correlated with abnormal uric acid(OR=1.603,95%CI:1.188-2.164),abnormal triglyceride(OR=1.619,95%CI:1.253-2.093)and abnormal fasting blood glucose(OR=1.565,95%CI:1.166-2.100),adjusting for confounding factors(gender,age,marital status,etc.).Conclusion The in⁃crease of SBP in adults were correlated with uric acid,blood lipid and blood glucose.