15例原发性甲状腺淋巴瘤的临床分析

Clinical analysis of 15 cases of primary thyroid lymphoma

目的通过分析原发性甲状腺淋巴瘤(PTL)的临床特点,总结该病的诊治经验,提高临床诊断及治疗水平。方法对2012—2021年就诊的15例PTL患者的临床资料进行回顾性分析。结果15例PTL患者中,男9例,女6例;年龄41~81岁,平均年龄58岁。起病时间0.06~36个月,平均10个月。15例患者中14例因颈部肿物就诊。常规病理类型均为非霍奇金淋巴瘤,包括8例弥漫性大B细胞淋巴瘤、6例黏膜相关淋巴组织淋巴瘤和1例滤泡淋巴瘤。15例患者中除3例失访外,随访患者中无复发,无患者死亡。结论PTL是一种罕见的甲状腺恶性肿瘤,临床上多表现为无痛性的颈部肿物,确诊依赖于病理组织学和免疫组织化学检查,病理类型以弥漫性大B细胞淋巴瘤为主。目前以化疗为主要治疗手段。

Objective To improve the level of clinical diagnosis and treatment of primary thyroid lymphoma(PTL)by analyzing its clinical characteristics,summarizing the diagnosis and treatment experience of this disease.Methods A retrospective study on clinical,radiological and pathological data was performed to 15 PTL patients diagnosed and treated in our hospital between 2012 and 2021.Results Of all the 15 patients,9 were male and 6 were female with an average age of 58 years(ranged from 41 to 81 years)at the time of diagnosis.The average time to clarify diagnosis was 10 months(ranged from 0.06 to 36 months).Of them,14 sought medical treatment for neck mass.All the patients were diagnosed with non-Hodgkin’s lymphoma.The pathological subtypes were diffuse large B cell lymphoma in 8 patients,mucosaassociated lymphoid tissue lymphoma in 6,and follicular lymphoma in the other one.Except for 3 lost to follow-up,no recurrence or death occurred in the other follow-up patients.Conclusions PTL is a rare thyroid malignancy,mainly manifested as painless neck masses in clinical practice.The diagnosis depends on histopathology and immunohistochemical examination,and the pathological type is mainly diffuse large B cell lymphoma.At present,chemotherapy is the main treatment.