老鹳草素抗骨质疏松症机制的研究进展

Research progress on the mechanism of geraniin against osteoporosis

老鹳草素(Ge)能够抑制破骨细胞(OC)的增殖分化和促进成骨细胞(OB)的增殖分化,促进骨髓间充质干细胞向成骨分化。本文通过检索近年来维普、中国知网、PubMed等数据库有关Ge治疗骨质疏松症的文献与研究,针对Ge参与的相关细胞和信号通路的文献资料加以综述,发现Ge抗骨质疏松症的作用机制主要是通过上调Wnt/β-catenin及成骨转录因子2的表达,促进OB的增殖分化;抑制RANKL诱导的核因子-κB的表达,来对OC的分化产生抑制作用。本文通过综述进一步探究Ge抗骨质疏松症的作用机制,为治疗骨质疏松症和研究新药物提供了新的方案和依据。

The ability of geraniin(Ge)to inhibit the proliferation and differentiation of osteoclasts(OC)and promote the proliferation and differentiation of osteoblasts(OB),promotes bone marrow mesenchymal stem cells towards osteogenic differentiation.This paper reviews the literature and studies on Ge for osteoporosis by searching the databases of Vipshop,CNKI,and PubMed in recent years,and reviews the literature on the relevant cellular and signaling pathways involved in Ge,the mechanism of action of Ge against osteoporosis is found to promote proliferation and differentiation of OB mainly through upregulation of Wnt/β-catenin and expression of osteogenic transcription factor 2;inhibition of RANKL-induced nuclear factor-κB expression to exert inhibitory effects on OC differentiation.This paper further explores the mechanism of action of Ge against osteoporosis through a review,which provides new options and basis for the treatment of osteoporosis and research of new drugs.