用于慢性创面治疗的局部抗菌肽制剂的研究进展

Research progress of local antimicrobial peptides preparation for chronic wound treatment

抗菌肽(AMPs)具有良好的抗菌性及促创面愈合作用,是传统抗生素的潜在替代物。然而,AMPs对外界环境敏感,作用时间短,在局部应用中受到限制。通过载体递送或改变剂型形成的新型局部AMPs制剂能够实现缓释AMPs、增强AMPs稳定性和优化生物效能的目的,在慢性创面的临床应用中显示出重要优势。迄今,已开发多种AMPs制剂,其形式包括纳米颗粒、水凝胶、负载纳米颗粒的水凝胶、自组装肽等。本文综述了AMPs的概况、抗菌活性及促创面愈合特性,当前研发的局部AMPs制剂类型,效能影响因素,讨论了AMPs制剂的未来发展前景。

Antimicrobial peptides(AMPs)have good antibacterial properties and promote wound healing,and are potential substitutes for traditional antibiotics.However,AMPs is sensitive to the external environment and has a short action time,which is limited in local applications.The novel local AMPs preparation formed by carrier delivery or change of dosage form can achieve the purpose of slow release of AMPs,enhance the stability of AMPs and optimize the biological efficiency,and show important advantages in the clinical application of chronic wounds.To date,a variety of AMPs preparation have been developed in the form of nanoparticles,hydrogels,nanoparticle supported hydrogels,and self-assembling peptides,etc.In this paper,the general situation,antibacterial activity,and wound healing promoting properties of AMPs,preparation type of local AMPs preparations currently developed,and efficacy influencing factors are reviewed.The future development prospect of AMPs is discussed.