基于情志致病理论探讨心理应激对斑秃的作用机制的研究进展

Research progress on the mechanism of psychological stress on alopecia areata based on the theory of emotional pathogenicity

斑秃是一种非瘢痕性炎症性脱发,研究表明心理应激与斑秃的发生发展密切相关。中医情志致病理论与现代医学的心理应激具有相似和共通之处,七情内伤、气血失调是斑秃的重要因素。本文主要基于中医情志致病理论,从神经-内分泌-免疫网络紊乱、氧化应激与炎症反应、头皮微循环障碍3个方面阐述心理应激对斑秃作用机制的影响,同时强调个体化心理干预对斑秃治疗的重要性,以期为临床诊治斑秃提供新思路。

Alopecia areata is a non-cicatricial inflammatory alopecia.Studies have shown that psychological stress is closely related to the occurrence and development of alopecia areata.There are similarities and commonalities between the theory of emotional pathogenicity in traditional Chinese medicine and psychological stress in modern medicine.The internal injury of seven emotions and the disorder of qi and blood are important factors of alopecia areata.Based on the theory of emotional pathogenicity in traditional Chinese medicine,this paper discusses the effect of psychological stress on the mechanism of alopecia areata from three aspects:neuro-endocrino-immune network disorder,oxidative stress and inflammatory response,scalp microcirculation disorder,and emphasizes the importance of individualized psychological intervention in the treatment of alopecia areata,with a view to providing new ideas for clinical diagnosis and treatment of alopecia areata.