启阳胶囊治疗肾虚血瘀型糖尿病阳痿的临床效果

Clinical effect of Qiyang Capsules on impotence in diabetes mellitus with kidney deficiency and blood stasis type

目的研究启阳胶囊治疗肾虚血瘀型糖尿病阳痿患者的临床效果。方法选取河北省保定市第二中心医院2017年3月至2019年6月收治的160例肾虚血瘀型糖尿病阳痿患者,通过抛硬币法将其分为对照组和观察组,对照组71例采取常规降糖治疗及小剂量5型磷酸二酯酶抑制剂,观察组89例加用启阳胶囊治疗,连续治疗1个月。比较两组临床疗效、治疗前后勃起功能国际问卷-5(IIEF-5)评分、改良的性生活质量调查表(mSLQQ-QoL)评分、勃起硬度(EHS)、性激素水平[睾酮(T)、雌二醇(E_(2))]及不良反应情况。结果观察组临床疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,两组IIEF-5、mSLQQ-QoL评分高于较治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组EHS分级情况优于治疗前,且观察组优于对照组,差异有统计学意义(P<0.05)。治疗后,两组T水平高于治疗前,且观察组高于对照组,两组E_(2)水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论启阳胶囊治疗肾虚血瘀型糖尿病阳痿能够有效改善勃起功能及硬度、提高性生活质量并调节性激素水平,无显著的不良反应。

Objective To study the clinical effect of Qiyang Capsules on impotence in diabetes mellitus with kidney deficiency and blood stasis type.Methods A total of 160 patients with kidney deficiency and blood stasis type diabetes mellitus impotence treated in the Second Central Hospital of Baoding,Hebei Province from March 2017 to June 2019 were selected and divided into control group and observation group by coin toss method.The control group(71 cases)received routine hypoglycemic treatment and low-dose phosphodiesterase type 5 inhibitor,and the observation group(89 cases)were treated with Qiyang Capsules,for one month.The clinical efficacy,international index of erectile function-5(IIEF-5)score,modified sexual life quality questionnaire-quality of life(mSLQQ-QoL)score,erectile hardness(EHS)grading,sex hormone levels(testosterone[T],testosterone estradiol[E_(2)])before and after treatment and adverse reactions of the two groups were compared.Results The clinical efficacy of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).After treatment,IIEF-5 and mSLQQ-QoL scores in two groups were higher than before treatment,and those in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,the EHS grading of the two groups was better than that before treatment,and that of the observation group was better than that of the control group,the differences were statistically significant(P<0.05).After treatment,T level in the two groups was higher than before treatment,and that in the observation group was higher than that in the control group,E_(2) level in the two groups was lower than before treatment,and that in the observation group was lower than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Qiyang Capsules can effectively improve erectile function and hardness,improve sexual life quality,and regulate sex hormone level in treatment of kidney deficiency and blood stasis type diabetes mellitus impotence,without significant adverse reactions.