二至丸加味联合雌孕激素序贯法预防宫腔粘连分离术后再粘连的临床效果

Clinical effect of modified Erzhi Pills combined with sequential estrogen and progesterone therapy on prevention of re-adhesion after intrauterine adhesion separation

目的观察二至丸加味联合雌孕激素序贯法预防宫腔粘连(IUA)分离术后再粘连的临床效果。方法选取2020年6月至2022年6月于临沂市中医医院行宫腔镜下冷刀粘连分离联合宫腔支撑球囊治疗的40例IUA患者,根据随机数字表法分为对照组与治疗组,每组20例。对照组术后予雌孕激素序贯治疗,治疗组于对照组治疗方案基础上加用二至丸加味,连续治疗3个月。比较两组患者治疗总有效率、治疗前后IUA评分以及粘连复发情况。结果治疗组治疗总有效率为85.0%,高于对照组的70.0%,差异有统计学意义(P<0.05)。治疗组患者治疗后IUA评分低于对照组(P<0.05)。治疗3个月后,治疗组再粘连总发生率(15.0%)低于对照组(30.0%),差异有统计学意义(P<0.05)。结论二至丸加味联合雌孕激素序贯法预防IUA分离术后再粘连的临床效果显著,值得临床推广。

Objective To observe the clinical effect of modified Erzhi Pills combined with sequential estrogen and progesterone therapy on prevention of re-adhesion after intrauterine adhesion(IUA)separation.Methods A total of 40 patients with IUA who were treated with hysteroscopic separation of intrauterine adhesion by cold knife combined with intrauterine support balloon in Linyi Traditional Chinese Medical Hospital from June 2020 to June 2022 were selected and divided into control group and treatment group by the random number table method,with 20 patients in each group.The control group was treated with sequential estrogen and progesterone therapy,while the treatment group was supplemented with modified Erzhi Pills on the basis of the control group,both two groups were treated continuously for 3 months.The total effective rate of treatment,the IUA scores before and after treatment,and the recurrence of adhesion were compared between the two groups.Results The total effective rate of the treatment group was 85.0%,which was higher than 70.0%of the control group,and the difference was statistically significant(P<0.05).After treatment,the IUA score in the treatment group was lower than that in the control group(P<0.05).After 3 months of treatment,the total incidence of re-adhesion in the treatment group(15.0%)was lower than that in the control group(30.0%),and the difference was statistically significant(P<0.05).Conclusion Modified Erzhi Pills combined with sequential estrogen and progesterone therapy on prevention of re-adhesion after intrauterine adhesion separation has remarkable effect,which is worthy of clinical promotion.