肿瘤性骨软化症^(68)Ga-DOTATATEPET/CT显像特点分析

Imaging Characteristics of ^(68)Ga-DOTATATE PET/CT in Tumor-Induced Osteomalacia

肿瘤性骨软化症(TIO)是一种罕见的副肿瘤综合征,由肿瘤分泌成纤维细胞生长因子23(FGF23)等促进尿磷排泄所致,典型临床特征为高磷酸盐尿、低磷血症和骨软化症。由于肿瘤体积小,生长缓慢,发病位置隐匿,故常导致定位困难。由于致病肿瘤高表达生长抑素受体,应用核医学功能影像技术生长抑素受体显像能够对TIO致病肿瘤进行诊断和定位,具有极高的灵敏度和特异性。本文回顾分析了25例应用^(68)Ga-DOTATATE生长抑素受体PET/CT显像成功诊断和定位TIO致病肿瘤的病例,对患者的临床特征、病理结果以及^(68)Ga-DOTATATE PET/CT显像的图像特点等进行分析,并与其他影像学诊断技术进行比较,证实^(68)Ga-DOTATATE PET/CT显像是首选能够成功诊断和定位TIO致病肿瘤的影像诊断技术。

Tumor-induced osteomalacia(TIO)is a rare paraneoplastic syndrome caused by tumors secreting fibroblast growth factor 23(FGF23)that promotes urinary phosphorus excretion.Thus,TIO is typically characterized by phosphoruria,hypophosphatemia,and osteomalacia.Diagnosis and localization of the tumor is often difficult due to its small size,slow growth and concealed location.Due to the high expression of somatostatin receptors in pathogenic tumors,nuclear medicine functional imaging,particularly somatostatin receptor imaging,is used for diagnosis and localization of culprit tumors with high sensitivity and specificity.Here we retrospectively analyze 25 cases in which ^(68)Ga-DOTATATE PET/CT successfully localized and diagnosed TIO culprit tumors.The clinical features,pathological results and image characteristics of ^(68)Ga-DOTATATE PET/CT imaging were analyzed and compared with other imaging diagnostic techniques.It was confirmed that ^(68)Ga-DOTATATE PET/CT imaging was the preferred imaging technique for successful diagnosis and localization of TIO pathogenic tumors.