摘要
骨为肾所主,肾藏精,精能生髓,肾精亏虚将导致骨髓化生减少,骨失髓养,日久则发展为骨痿。线粒体是生命活动的“动力工厂”,人体细胞的增殖分化与凋亡有赖于线粒体正常的功能及相关信号通路的正常表达。中医认为元气藏于肾依赖于肾精充足,主导人的生长发育、激发代谢等生命活动的功能与现代医学中调控细胞生命活动的线粒体相似。水为肾所主,肾作为人体津液代谢的重要脏器之一,主要通过气化功能参与津液的输布和排泄,其功能失常将导致津液无以运化,壅聚成痰,随着近期对肾和津液关系研究的深入,“肾痰”理论逐渐深入人心。“百病多由痰作祟”,随着衰老的进行,肾精逐渐亏虚,肾气化生不足,将导致津液代谢失常而生“肾痰”,进而导致各种疾病的发生。氧化应激反应是多种疾病发生的危险因素,而作为其发生的重要影响因素,氧化自由基的蓄积与机体衰老有关,由此看来痰和氧化自由基无论在生成还是致病特点上都存在许多共同点。相关研究表明氧化应激引起的成骨细胞过量凋亡会导致骨质疏松发生的风险增加,其主要机制与线粒体功能的损害及Wnt/β-catenin等相关信号通路表达的失常明显相关。故本文从“痰之本在肾”探讨线粒体氧化应激与骨质疏松症之间的关系。
Abstrac:Bone is the master of kidney,the essence resides in the kidney,essence can produce pulp,kidney essence deficiency will lead to the reduction of bone marrow metaplasia,bone loss pulp nourishing,over time is the development of bone wilt.Mitochondria are the“power factories”of life activities.The proliferation,differentiation and apoptosis of human cells depend on the normal function and the normal expression of related signaling pathways of mitochondria.Traditional Chinese medicine believes that Yuan Qi resides in the kidney,depending on sufficient kidney essence,and its functions of leading human growth and development,stimulating metabolism and other life activities are similar to those of mitochondria regulating cell life activities in modern medicine.Kidney,as one of the important organs of body fluid metabolism,is mainly involved in body fluid transport and excretion through gasification function.Its dysfunction will also lead to body fluid transport,thereby obstructing accumulation of sputum.With the recent in-depth research on the relationship between kidney and body fluid,the theory of“kidney phlegm”has gradually gained popular support.“Most diseases are caused by phlegm”,with the progress of aging,kidney essence gradually deficient,kidney qi deficiency,will lead to body fluid metabolism disorder and produce“kidney sputum”,and then lead to the occurrence of various diseases.Oxidative stress reaction is a risk factor for a variety of diseases.As an important factor affecting the occurrence of oxidative stress reaction,the accumulation of oxidative free radicals is related to the aging of the body.Relevant studies have shown that excessive apoptosis of osteoblasts caused by oxidative stress will lead to increased risk of osteoporosis.The main mechanism is related to the damage of mitochondrial function and the abnormal expression of Wnt/β-catenin and other related signaling pathways.Therefore,sputum and oxidative free radicals have a lot in common in both the generation and pathogenic characteristics.Therefore,this paper discusses the relationship between mitochondrial oxidative stress and osteoporosis based on the theory of"kidney is the root of phlegm".
作者
李泽锋
黄文锋
胡洲映
苏畅怡
LI Zefeng;HUANG Wenfeng;HU Zhouying;SU Changyi(Guangzhou University of Chinese Medicine,Guangzhou 510006,China;Zhanjiang First Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine,Zhanjiang 524000,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2023年第8期1182-1185,1191,共5页
Chinese Journal of Osteoporosis
基金
湛江市科技发展专项资金竞争性分配项目(2022A01068)。
关键词
“肾痰”
骨质疏松症
线粒体
氧化应激
kidney sputum
osteoporosis
mitochondria
oxidative stress