5-氨基酮戊酸光动力疗法联合手术治疗皮肤基底细胞癌的疗效及安全性

Efficacy and safety of 5-aminolaevulinic acid photodynamic therapy combined with surgery for skin basal-cell carcinoma

目的 探讨5-氨基酮戊酸光动力疗法(ALA-PDT)联合手术治疗皮肤基底细胞癌的疗效及安全性。方法根据治疗方法的不同将80例皮肤基底细胞癌分为手术组(n=35)与联合组(n=45),手术组患者给予单纯手术治疗,联合组患者给予手术联合ALA-PDT治疗。手术组患者采用单纯手术治疗,联合组患者在手术组的基础上联合ALA-PDT进行治疗。比较两组患者临床疗效、愈合情况、美容效果、并发症发生情况和复发情况。结果联合组患者的总有效率为97.78%,高于手术组患者的80.00%,差异有统计学意义(P﹤0.05)。治疗后,联合组患者的Ⅰ期愈合率、美容优良率均明显高于手术组,差异均有统计学意义(P﹤0.01)。联合组患者的并发症总发生率和复发率均低于手术组,差异均有统计学意义(P﹤0.05)。结论 ALA-PDT联合手术治疗皮肤基底细胞癌的疗效确切,Ⅰ期愈合率较高,美容效果较好,同时可降低并发症发生率和复发率,安全可靠。

Objective To investigate the efficacy and safety of 5-aminolaevulinic acid photodynamic therapy(ALAPDT)combined with surgery for skin basal-cell carcinoma.Method According to the different treatment methods,80 cases of skin basal-cell carcinoma were divided into the operation group(n=35)and the combination group(n=45).The patients in the operation group were treated with surgery alone,and the patients in the combination group were treated with surgery combined with ALA-PDT.Compared the clinical efficacy,healing status,cosmetic effect,complications,and recurrence of two groups.Result The total effective rate of patients in the combined group was 97.78%,higher than 80.00%in the operation group,the difference was statistically significant(P<0.05).After treatment,the I stage healing rate and cosmetic excellence rate of patients in the combined group were significantly higher than those in the operation group,the differences were statistically significant(P<0.01).The total incidence and recurrence rate of complications in the combined group were lower than those in the operation group,the differences were statistically significant(P<0.05).Conclusion ALA-PDT combined with surgery for skin basal-cell carcinoma has a definite curative effect.It has a I stage healing rate,cosmetic excellence rate,and can reduce the incidence of complications and recurrence rate.It is safe and reliable.