摘要
IL-33是白细胞介素1家族来源的核细胞因子,通过其受体作用于多种细胞,如肥大细胞、2型固有淋巴细胞、嗜碱性粒细胞,是2型免疫反应发生及维持的重要细胞因子之一。近年来研究表明,IL-33激活外周神经系统参与瘙痒信号的传递。本文回顾了IL-33介导受体激活的信号转导机制/2型炎症皮肤病中IL-33参与瘙痒的神经免疫机制及IL-33靶向药物研究进展。
IL-33 is a nuclear cytokine of the IL-1 family,which acts on a variety of cells through combination its receptors,such as mast cells,innate lymphocytes type 2,basophils,etc..It is one of the important cytokines in the development and maintenance of type 2 immune responses.Recent studies have shown that IL-33 is involved in pruritic signaling through activating the peripheral nervous system.This paper focuses on the signal transduction mechanism after the activation of interleukin 33 receptor,and elaborates the neuroimmune mechanism of IL-33 involved in pruritus in type 2 inflammatory skin diseases.We also review the advances of drug research targeting IL-33.
作者
周灵萱
赵洋
袁晓辉
徐哲
刘玲玲
汪旸
赵嘉惠
ZHOU Lingxuan;ZHAO Yang;YUAN Xiaohui;XU Zhe;LIU Lingling;WANG Yang;ZHAO Jiahui(Department of Dermatology,Peking University First Hospital&Beijing Key Laboratory of Molecular Diagnosis on Dermatoses&National Clinical Research Center for Skin and Immune Disease&NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics,Beijing 100034,China;Shunyi Maternal and Children s Hospital of Beijing Children s Hospital,Beijing 101300,China;Department of Dermatology,Beijing Children s Hospital,Capital Medical University&National Center for Children s Health,Beijing 100045,China)
出处
《中国麻风皮肤病杂志》
2023年第9期688-692,共5页
China Journal of Leprosy and Skin Diseases
基金
国家自然科学基金青年项目(编号:81903213)
北京脑科学与类脑研究中心科研合作开放基金项目(编号:2020-NKX-XM-08)。
关键词
IL-33
瘙痒
2型炎症
神经免疫
interleukin-33
pruritus
type 2 inflammation
neuroimmunity
