拉坦前列素与噻吗洛尔不同联用方案治疗原发性开角型青光眼的临床疗效和安全性观察

Observation on Clinical Efficacy and Safety of Different Combination Regimens of Latanoprost and Timolol in the Treatment of Primary Open Angle Glaucoma

目的观察拉坦前列素与噻吗洛尔不同联用方案治疗原发性开角型青光眼的临床有效性和安全性。方法选取2019年5月-2022年5月在我院诊治的72例原发性开角型青光眼患者为研究对象,采用随机数字表法分为对照组和观察组,各36例。两组均给予拉坦前列素联合噻吗洛尔治疗,观察组噻吗洛尔每天给药1次,对照组噻吗洛尔每天给药2次,比较两组临床疗效、视力、24 h平均眼压、散光度、视野缺损评分、视网膜神经纤维层厚度及不良反应发生率。结果观察组总有效率为94.44%,与对照组91.67%比较,差异无统计学意义(P>0.05);两组治疗后视力均高于治疗前,24 h平均眼压、散光度均低于治疗前,且两组间比较,差异无统计学意义(P>0.05);两组治疗后视野缺损评分均低于治疗前,视网膜神经纤维层厚度大于治疗前,且两组间比较,差异无统计学意义(P>0.05);观察组不良反应发生率为5.56%,低于对照组的16.67%(P<0.05)。结论拉坦前列素与噻吗洛尔联合治疗原发性开角型青光眼总有效率较高,且减少噻吗洛尔的给药次数不仅对临床疗效无影响,还可以降低不良反应发生率、改善视野受损和视网膜神经纤维层厚度,具有较理想的疗效和安全性。

Objective To observe the clinical efficacy and safety of different combination regimens of latanoprost and timolol in the treatment of primary open angle glaucoma.Methods A total of 72 patients with primary open angle glaucoma diagnosed and treated in our hospital from May 2019 to May 2022 were selected as the research objects.They were divided into control group and observation group by random number table method,with 36 patients in each group.Both groups were treated with latanoprost combined with timolol,while the observation group was given timolol once a day,and the control group was given timolol twice a day.The clinical efficacy,visual acuity,24 h average intraocular pressure,astigmatism,visual field defect score,retinal nerve fiber layer thickness and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 94.44%,which was compared with 91.67%of the control group,the difference was not statistically significant(P>0.05).The visual acuity of the two groups after treatment was higher than that before treatment,and the average intraocular pressure and astigmatism at 24 h were lower than those before treatment,and there was no significant difference between the two groups(P>0.05).After treatment,the visual field defect scores of the two groups were lower than those before treatment,and the retinal nerve fiber layer thickness was greater than that before treatment,and there was no significant difference between the two groups(P>0.05).The incidence of adverse reactions in the observation group was 5.56%,which was lower than 16.67%in the control group(P<0.05).Conclusion The total effective rate of latanoprost combined with timolol in the treatment of primary open-angle glaucoma is higher,and reducing the number of administration of timolol not only has no effect on the clinical efficacy,but also can reduce the incidence of adverse reactions,improve visual field damage and retinal nerve fiber layer thickness,with ideal efficacy and safety.