血维生素K_(2)和IL-6水平与慢性肾脏病患者冠状动脉钙化的相关性研究

Correlation of serum vitamin K_(2) and IL-6 levels with coronary artery calcification in chronic kidney disease patients

目的探讨血维生素K_(2)和白细胞介素6(interleukin-6,IL-6)水平与慢性肾脏病(chronic kidney disease,CKD)患者冠状动脉钙化(coronary artery calcification,CAC)的相关性。方法选取2019年1月至2022年6月温州市人民医院肾内科收治的CKD患者111例,采用酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)检测血维生素K_(2)和IL-6水平;通过Agatston评分评价CAC;分析维生素K_(2)、IL-6与CAC的相关性。结果CAC组的年龄、高敏C反应蛋白(hypersensitive-C-reactive-protein,hs-CRP)、血磷、甲状旁腺素(parathyroid hormone,PTH)、同型半胱氨酸(homocysteine,Hcy)、IL-6水平较非CAC组高,而估算肾小球滤过率(estimated glomerular filtration rate,eGFR)、维生素K_(2)较非CAC组低;Logistic回归分析显示年龄、Hcy、IL-6是CAC独立危险因素(OR值分别为1.69、1.14及1.12,95%CI分别为1.237~2.181、1.005~1.623、1.014~1.328);eGFR、维生素K_(2)为CAC的保护因素(OR值分别为0.328、0.243,95%CI分别为0.216~0.713、0.076~0.651);重度CAC组维生素K_(2)较轻度CAC组降低,IL-6则较轻度CAC组、中度CAC组升高(F值分别为5.70、6.13,P<0.05)。结论高龄、高Hcy、高IL-6水平是CAC的独立危险因素,eGFR和维生素K_(2)是CAC的保护因素。

Objective To investigate the correlation of serum vitamin K_(2) and interleukin-6(IL-6)levels with coronary artery calcification(CAC)in chronic kidney disease(CKD)patients.Methods A total of 111 patients who admitted to the department of nephrology in Wenzhou People’s Hospital for chronic kidney disease during January 2019 to June 2022 were collected and divided into different groups.The levels of serum vitamin K_(2) and IL-6 were detected by enzyme linked immunosorbent assay(ELISA).Chest CT was assessed by Agatston score;The relationship between vitamins K_(2),IL-6 and CAC was analyzed.Results The levels of age,hypersensitive-C-reactive-protein(hs-CRP),phosphorus,parathyroid hormone(PTH),homocysteine(Hcy),and IL-6 were higher in the CAC group than those in the non-CAC group,while estimated glomerular filtration rate(eGFR)and vitamin K_(2) were lower than those in the non-CAC group.By logistic regression analysis,advancde age,high levels of Hcy and IL-6 were independent risk factors for CAC(OR were 1.69,1.14 and 1.12,95%CI were 1.237-2.181,1.005-1.623,1.014-1.328,respectively).eGFR,vitamin K_(2) were protective factors of CAC(OR were 0.328,0.243,95%CI were 0.216-0.713,0.076-0.651);Vitamin K_(2) in the severe CAC group was lower than in the mild CAC group,while IL-6 was higher in the mild、moderate groups than the severe CAC group(F were 5.70,6.13,P<0.05).Conclusion Advancde age,high levels of Hcy and IL-6 were independent risk factors for CAC,while eGFR and vitamin K_(2) were the protective factors for CAC.