移植肾间质纤维化与抗纤维化研究进展

Research progress of renal allograft interstitial fibrosis and anti-fibrosis

移植肾间质纤维化是慢性移植肾功能不全(chronic allograft dysfunction,CAD)的主要病理表现,也是造成移植肾长期存活率低的主要原因。多种因素及作用机制可直接或间接导致间质纤维化的发生,如何预防以及减缓移植肾间质纤维化进程是当前亟待解决的难题。因此,本文总结了近年来国内外关于移植肾间质纤维化主要发生机制及抗间质纤维化方面取得的进展。

Renal allograft interstitial fibrosis is the main pathological manifestation of chronic allograft dysfunction(CAD),which is also the main reason foRthe low long-term survival of renal allograft.A variety of factors and mechanisms can directly oRindirectly lead to the occurrence of interstitial fibrosis.It is urgent to prevent and slow down the process of interstitial fibrosis in renal transplantation.Therefore,this article summarizes the progress of the main mechanisms of renal allograft interstitial fibrosis and the anti-fibrosis strategies in recent years.