非酒精性脂肪肝的临床危险因素与药物使用情况

Analysis of clinical risk factors foRnonalcoholic fatty liveRdisease and the drug use

目的分析非酒精性脂肪肝患者可能的临床危险因素,以及其用药情况。方法选取2021年1~12月收治的非酒精性脂肪性肝病(NAFLD)患者共100例纳入研究组,并选取同期院体检中心记载的120例健康人作为对照组;比较2组临床一般性资料指标,以及应用Logistic回归预测NAFLD患者的独立风险因素;并记录部分NAFLD患者临床用药的特点。结果在临床一般性资料指标中,除年龄和性别因素外,其他临床指标在2组间均存在显著性差异(P<0.05);Logistic回归显示:肥胖、高血脂、糖尿病、不良生活习惯和高尿酸血症可作为NAFLD患者的独立风险因素,在拟合模型中差异均有统计学意义(P<0.05);部分中重度的NAFLD患者经辅助用药后均有所缓解,药物类型主要为熊去氧胆酸、多烯磷脂酰胆碱和复方甘草酸苷。结论非酒精性脂肪肝与机体内的糖脂代谢有关,肥胖、高血脂和糖尿病也作为其主要的独立风险预测因素,而不良生活习惯和高尿酸血症也与NAFLD的发生密切相关。在今后的临床诊疗过程中应全面分析潜在的危险因素,做到早诊早治。

Objective To analyze the potential clinical risk factors foRnonalcoholic fatty liveRdisease(NAFLD),and the drug use.Methods A total of 100 NAFLD patient admitted to ouRhospital from January 2021 to DecembeR2021 were included in the study group,and 120 healthy subject recorded in the physical examination centeRof ouRhospital during the same period were selected as the control group.General clinical data were compared between the two groups,and independent risk factors foRNAFLD were predicted by Logistic regression.The characteristics of drug use in some NAFLD patients were recorded.Results There were significant differences in otheRgeneral clinical data between the two groups except foRage and gendeR(P<0.05).Logistic regression analysis showed that in the fitting model,obesity,hyperlipidemia,diabetes,bad lifestyle habits and hyperuricemia were independent risk factors foRNAFLD patients(P<0.05).Some moderate and severe NAFLD patients were relieved afteRadjuvant medications,mainly including ursodeoxycholic acid,polyene phosphatidyl choline and compound glycyrrhizin.Conclusion NAFLD is related to the metabolism of glucose and lipid in the body.Obesity,hyperlipidemia and diabetes are also the main independent risks foRNAFLD,and bad lifestyle habits and hyperuricemia are also closely related to the occurrence of NAFLD.In the future clinical diagnosis and treatment process,a comprehensive analysis of potential risk factors is needed to achieve early diagnosis and treatment.