门冬胰岛素联合地特胰岛素治疗妊娠糖尿病的临床效果

Clinical Effect of Insulin Aspart Combined with Insulin Detemir in the Treatment of Gestational Diabetes Mellitus

目的 分析门冬胰岛素联合地特胰岛素治疗妊娠糖尿病的效果。方法 选取2020年8月-2022年3月菏泽市牡丹区中医医院的70例妊娠糖尿病患者为研究对象,行数字法将患者均分为两组,各35例,以门冬胰岛素治疗为对照组,联合地特胰岛素治疗为观察组,从血糖达标时间、血糖变化等多项指标对疗效进行观察评估。结果 观察组空腹血糖、餐后2 h血糖达标时间和二者均达标时间短于对照组,差异有统计学意义(P<0.05)。治疗前,两组血糖水平比较,差异无统计学意义(P>0.05),治疗后,观察组空腹血糖、餐后2 h血糖低于对照组,差异有统计学意义(P<0.05)。治疗前,两组各临床指标比较,差异无统计学意义(P>0.05),治疗后,观察组同型半胱氨酸、胰岛素抵抗指数均低于对照组,差异有统计学意义(P<0.05)。观察组不良妊娠反应少于对照组,差异有统计学意义(P<0.05)。结论 将门冬胰岛素和地特胰岛素合用,可有效控制妊娠糖尿病血糖,改善其临床治疗,减少疾病对母婴安全的影响,降低不良妊娠结局风险。

Objective To analyze the effect of insulin aspart combined with insulin detemir in the treatment of gestational diabetes mellitus.Methods From August 2020 to March 2022,70 patients with gestational diabetes in the Mudan District Hospital of Traditional Chinese Medicine in Heze City were selected as the research objects.The patients were divided into two groups by the numerical method,35 cases in each group.The control group was treated with insulin aspart,and the observation group was treated with insulin detemir.The curative effect was observed and evaluated from multiple indicators,such as blood glucose reaching target time and blood glucose changes.Results The time of reaching the standard of fasting plasma glucose,2-hour postprandial blood glucose and both of them in the observation group were shorter than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in blood glucose levels between the two groups(P>0.05).After treatment,the fasting plasma glucose and 2-hour postprandial blood glucose in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference between the two groups in terms of clinical indicators(P>0.05).After treatment,the homocysteine and insulin resistance index in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The adverse pregnancy reactions in the observation group were less than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Combining insulin aspart and insulin detemir can effectively control blood sugar in gestational diabetes,improve its clinical treatment,reduce the impact of the disease on maternal and child safety,and reduce the risk of adverse pregnancy outcomes.