探讨达格列净药物治疗糖尿病合并重型颅脑损伤患者的临床效果

Exploring the Clinical Effect of Dapagliflozin in the Treatment of Diabetes Mellitus Patients with Severe Craniocerebral Injury

目的 探讨糖尿病合并重型颅脑损伤患者接受达格列净药物治疗后的临床治疗效果。方法 选取2020年3月-2022年12月石狮市医院收治的64例糖尿病合并重型颅脑损伤患者。按照数字随机表法分为对照组(在对症治疗基础上口服盐酸二甲双胍缓释片药物治疗方法)和观察组(在对照组基础上联合达格列净药物治疗方法),每组32例。采用统计学分析两组临床治疗总有效率、血糖达标时间、住院时间、不良反应、脑脊液蛋白水平、胰岛β细胞功能指数(functional index of islet β cells, HOMA-β)、稳态模型胰岛素抵抗指数(homeostatic model of the insulin resistance index, HOMA-IR)。结果 观察组临床治疗总有效率明显高于对照组,差异有统计学意义(P<0.05)。观察组患者的血糖达标及住院时间明显短于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。治疗前,两组血糖水平、脑脊液蛋白水平、HOMA-IR以及HOMA-β等指标比较,差异无统计学意义(P>0.05),治疗后,观察组患者的血糖水平、脑脊液蛋白水平、HOMA-IR均明显低于对照组,HOMA-β高于对照组,差异有统计学意义(P<0.05)。结论 糖尿病合并重型颅脑损伤患者接受达格列净药物治疗后效果显著,与此同时具有较高的安全性且可积极改善其血糖、HOMA-IR、HOMA-β水平等。

Objective To explore the clinical therapeutic effect of dapagliflozin in patients with diabetes mellitus complicated with severe craniocerebral injury.Methods 64 patients with diabetes mellitus and severe traumatic brain injury admitted to Shishi Hospital from March 2020 to December 2022 were selected.According to the digital random table method,they were divided into the control group(on the basis of symptomatic treatment,oral metformin hydrochloride sustained-release tablet drug treatment)and the observation group(combined with dapagliflozin drug treatment on the basis of the control group),each group included 32 cases.Statistical analysis was used to analyze the total effective rate of clinical treatment,time to reach blood glucose standard,hospitalization time,adverse reactions,cerebrospinal fluid protein level,homeostasis model assessment-β(HOMA-β),homeostasis model assessment-insulin resistance(HOMA-IR)in the two groups of patients.Results The total effective rate of clinical treatment in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).The blood glucose standard time and hospitalization time of the observation group were significantly shorter than those of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Before treatment,there was no statistical significance in blood glucose level,cerebrospinal fluid protein level,HOMA-IR and HOMA-βbetween the two groups of patients(P>0.05).After treatment,the blood glucose level,cerebrospinal fluid protein level,HOMA IR in the observation group were significantly lower than those in the control group,the HOMA-βwere higher than those of the control group,and the difference was statistically significant(P<0.05).Conclusion For patients with diabe‐tes mellitus complicated with severe craniocerebral injury,dapagliflozin drug treatment has a significant effect.At the same time,it has high safety and can actively improve blood glucose,HOMA-IR,HOMA-βlevels,etc.