糖尿病视网膜病变患者血清Cys-C、Hcy及血脂的表达及相关分析

Expression and Correlation Analysis of Serum Cys-C,Hcy and Blood Lipids in Patients with Diabetic Retinopathy

目的 探究糖尿病视网膜病变患者血清血清胱抑素C、同型半胱氨酸及血脂的表达及相关分析。方法 选取2021年1月-2022年1月诏安县医院收治的2型糖尿病患者201例,根据是否患有视网膜病变以及视网膜病变是否有增生将其分为2型糖尿病组(73例)、非增生组(63例)和增生组(65例),并选取同期于本院进行体检的60例健康者作为健康组。对比4组血清胱抑素C、同型半胱氨酸、血脂总胆固醇、三酰甘油、低密度脂蛋白胆固醇及高密度脂蛋白胆固醇的水平,分析其与患者视网膜病变的关系和患视网膜病变的影响因素。结果 2型糖尿病组、非增生组和增生组患者的血清胱抑素C、同型半胱氨酸、血脂总胆固醇、三酰甘油、低密度脂蛋白胆固醇及高密度脂蛋白胆固醇水平均明显高于健康组人群,差异有统计学意义(P<0.05)。Spearman相关性结果显示,血清胱抑素C、同型半胱氨酸、血脂总胆固醇、三酰甘油、低密度脂蛋白胆固醇及高密度脂蛋白胆固醇水平与患者是否伴有视网膜病变呈现正相关关系(P<0.05)。Logistic回归分析显示,血清胱抑素C、同型半胱氨酸、血脂总胆固醇、三酰甘油是患视网膜病变的独立危险因素(P<0.05)。结论 血清胱抑素C、同型半胱氨酸、血脂总胆固醇、三酰甘油的高表达水平是患者患视网膜病变的危险因素,且其水平在糖尿病视网膜病变患者中随病情的严重程度而增加,可作为观察期病情严重程度的指标。

Objective To explore the expression and correlation analysis of serum Cys-C,Hcy and blood lipids in patients with diabetic retinopathy.Methods 201 patients with type 2 diabetes admitted to Zhao'an County Hospital from January 2021 to January 2022 were divided into type 2 diabetes group(73 cases),non proliferative group(63 cases)and proliferative group(65 cases)according to whether they had retinopathy and whether retinopathy had hyperplasia.60 healthy people who had physical examination in our hospital at the same time were selected as the healthy group.Compared the levels of serum cystatin,homocysteine,blood lipids total cholesterol,triglycerides,low density lipoprotein cholesterol,and high density lipoprotein cholesterol in four groups.Analyzed the relationship betwee their levels and retinopathy,as well as the influencing factors of retinopathy.Results The serum levels of serum cystatin,homocysteine,blood lipids total cholesterol,triglycerides,low density lipoprotein cholesterol,and high density lipoprotein cholesterol in the patients with type 2 diabetes group,non proliferative and proliferative groups were significantly higher than those in the healthy group,the difference was statistically significant(P<0.05).Spearman correlation results showed that the levels of serum Cystatin C,homocysteine,total cholesterol of blood lipids,triacylglycerol,low-density lipoprotein cholesterol and High-density lipoprotein cholesterol were positively correlated with whether the patient had retinopathy or not(P<0.05).Logistic regression analysis showed that serum cystatin,homocysteine,blood lipids to‐tal cholesterol,triglycerides were independent risk factors for retinopathy(P<0.05).Conclusion The high expression levels of serum cystatin,homocysteine,blood lipids total cholesterol,triglycerides are risk factors for patients with reti‐nopathy,and their levels increase with the severity of the disease in patients with diabetic retinopathy,which can be used as indicators of the severity of the disease during the observation period.