吡啶及喹啉氮氧化物C2-H键官能团化反应的最新进展

Recent progress in C2–H functionalization of pyridine and quinoline N-oxides

以吡啶及喹啉为代表的含氮杂环化合物在天然产物及药物中分布广泛,发展其芳环上C–H键官能团化反应一直是化学中的前沿及重点研究领域.由于吡啶及喹啉氮氧化物价廉易得,基于氮氧化物化学的反应方法在其环上引入各类官能团应用非常广泛.本文主要综述了近三年吡啶及喹啉氮氧化物C2–H键转化为其他化学键的研究进展,讨论了反应机理及合成方法的亮点,并对未来该研究领域的发展方向进行了展望.

Nitrogen-containing heterocyclic compounds,such as pyridine and quinoline,are widely distributed in natural products and drugs.The development of their aromatic C–H bond functionalization has always been the frontier and key research area in chemistry.Because pyridine and quinoline N-oxides are inexpensive and readily available,reaction methods based on pyridine and quinoline N-oxides chemistry have been widely used to introduce various functional groups into heterocycles.In this paper,the research progress for the conversion of C2–H bonds in pyridine and quinoline N-oxides into other chemical bonds in the past three years is reviewed.The reaction mechanism and the highlights of the synthetic methodology are discussed,and the development direction of this research field in the future is demonstrated.