郑州市金水区健康体检人群高尿酸血症患病现状及影响因素

Status and Influencing Factors of Hyperuricemia Among Healthy People in Jinshui Area of Zhengzhou City

目的分析郑州市金水区健康体检人群高尿酸血症患病现状及影响因素。方法回顾性收集2020年1月至2022年12月郑州市金水区行健康体检者10740例的临床资料,根据体检结果是否为高尿酸血症将患者分为高尿酸血症组(1987例)、非高尿酸血症组(8753例),对比不同年龄段、性别间血尿酸水平、高尿酸血症检出率,统计两组的一般资料并进行比较,采用多因素logistic回归分析影响健康体检人群高尿酸血症患病的危险因素。结果男性、女性均随着年龄的增加,尿酸血症检出率逐渐增加(经趋势性χ^(2)检验,P<0.001)。和女性进行比较,各个年龄阶段男性的尿酸水平、高尿酸血症检出率均相对更高,且随着年龄的增加,尿酸水平也随之不断升高。高尿酸血症组中性别为男性,有高血压、高脂血症、脂肪肝的患者占比,体重指数(BMI)、血清尿素、肌酐、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)水平和舒张压、收缩压均高于非高尿酸血症组,血清HDL-C水平低于非高尿酸血症组。多因素logistic分析结果显示,性别为男性,BMI较高,患有高血压、高脂血症、脂肪肝,血清尿素、肌酐、TC、TG及LDL-C水平和舒张压、收缩压升高,血清HDL-C水平降低均为影响健康体检人群高尿酸血症患病的危险因素(P<0.05)。结论影响健康体检人群高尿酸血症患病的危险因素包括男性,BMI较高,患有高血压、高脂血症、脂肪肝,血清尿素、肌酐、TC、TG及LDL-C水平和舒张压、收缩压升高,血清HDL-C水平降低,临床可据此对有以上特征的患者进行针对性干预措施,以降低临床高尿酸血症的发生率。

Objective To analyze the status and influencing factors of hyperuricemia among healthy people in Jinshui area of Zhengzhou city.Methods Clinical data of 10740 healthy patients who underwent physical examination in Jinshui area of Zhengzhou city from January 2020 to December 2022 were retrospectively collected.According to physical examination results,patients were divided into the hyperuricemia group(1987 cases)and the non-hyperuricemia group(8753 cases).Serum uric acid(UA)level and detection rate of hyperuricemia were compared between different age groups and genders.General data of the two groups were collected and compared.Multivariate logistic regression was used to analyze the risk factors of hyperuricemia in healthy people.Results With the increase of age,the detection rate of uricemia in both men and women gradually increased(by trendχ^(2) test,P<0.001).Compared with females,the level of UA and the detection rate of hyperuricemia were higher in males at all ages,and the UA level increased with the increase of age.The proportion of patients with hypertension,hyperlipidemia and fatty liver,body mass index(BMI),serum urea,creatinine,total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)levels,diastolic blood pressure(DBP)and systolic blood pressure(SBP)in the hyperuricemia group were higher than that of the non-hyperuricemia group.Serum HDL-C level was lower than that of the non-hyperuricemia group.Multivariate logistic analysis results showed that male,higher BMI,suffering from hypertension,hyperlipidemia,fatty liver,serum urea,creatinine,TC,TG and LDL-C levels,DBP,SBP increased,serum HDL-C level decreased were all risk factors affecting hyperuricemia in healthy physical examination population(P<0.05).Conclusion The risk factors affecting hyperuricemia in healthy physical examination population include male,higher BMI,hypertension,hyperlipidemia,fatty liver,serum urea,creatinine,TC,TG and LDL-C levels,DBP,SBP increased,serum HDL-C level decreased.Clinical targeted intervention measures can be carried out for patients with the above characteristics,to reduce the incidence of clinical hyperuricemia.