抗新型冠状病毒药物研究进展

Research progress on anti SARS-CoV-2 drugs

新型冠状病毒(Severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)感染产生的严重急性呼吸系统综合征,可对人体产生严重损害甚至威胁生命,因此研发出安全、有效的抗病毒药物刻不容缓。SARS-CoV-2蛋白结构的解析及其感染机制的揭示,为抗病毒药物的研发提供了重要理论基础。本文综述了国内外科研团体对SARS-CoV-2的结构、感染通路和抗病毒药物的研发进展,重点讲述了多个抗病毒分子的研究概况,并对抗SARS-CoV-2药物的研发提出了一些展望。

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a severe acute respiratory syndrome that can cause serious damage to the human body and even threatens the life.Therefore,it is urgent to develop safe and effective antiviral drugs.The analysis of the structure of SARS-CoV-2 protein and the revelation of the infection mechanism have provided an important theoretical basis for the research and development of antiviral drugs.This review summarizes the structure,infection pathway and antiviral drug research and development progress of SARS-CoV-2 by domestic and foreign scientific research groups,focuses on the research overview of various antiviral molecules,and proposes future prospects for anti SARS-CoV-2 drug research and development.