依达拉奉联合血栓通注射液治疗急性脑梗死对其炎症反应的影响

Effect of Edaravone Combined with Xueshuantong Injection on the Inflam⁃matory Response of Acute Cerebral Infarction

目的分析给予急性脑梗死患者依达拉奉联合血栓通注射液治疗对其炎症反应带来的影响。方法选择2020年9月—2022年3月齐齐哈尔医学院附属第三医院诊治的82例急性脑梗死患者为研究对象,分组处理中实施双盲法,将患者均分为分析组和参考组,每组41例。参考组实施血栓通注射液治疗,分析组在此基础上加用依达拉奉治疗,比较组间临床疗效、神经功能、炎症反应、凝血功能、血管内皮功能、不良反应。结果分析组临床有效率为97.56%,高于参考组的78.05%,差异有统计学意义(χ^(2)=7.289,P=0.007)。治疗后,分析组神经功能、炎症反应各指标、凝血功能、血管内皮功能优于参考组,差异有统计学意义(P<0.001)。分析组不良反应发生率为2.44%,低于参考组为19.51%,差异有统计学意义(χ^(2)=4.493,P=0.034)。结论在急性脑梗死治疗中应用依达拉奉联合血栓通注射液治疗,不但可以提高临床疗效,缓解炎症反应,还能够改善神经功能,有效调节凝血功能,也有利于血管内皮功能的提升,促进不良反应的减少。

Objective To analyze the effect of edaravone combined with Xueshuantong injection on inflammatory re⁃sponse in patients with acute cerebral infarction.Methods A total of 82 patients with acute cerebral infarction diag⁃nosed and treated in the Third Affiliated Hospital of Qiqihar Medical College from September 2020 to March 2022 were selected as the research objects.The double-blind method was implemented in the grouping process,and the pa⁃tients were divided into analysis group and reference group,with 41 cases in each group.The reference group was treated with Xueshuantong injection,and the analysis group was treated with edaravone on this basis.The clinical effi⁃cacy,neurological function,inflammatory response,coagulation function,vascular endothelial function and adverse re⁃actions were compared between the two groups.Results The clinical effective rate of the analysis group was 97.56%,which was higher than 78.05%of the reference group,and the difference was statistically significant(χ^(2)=7.289,P=0.007).After treatment,the neurological function,inflammatory response indexes,coagulation function and vascular endothelial function of the analysis group were better than those of the reference group,and the differences were statis⁃tically significant(P<0.001).The incidence of adverse reactions in the analysis group was 2.44%,which was lower than that in the reference group(19.51%),and the difference was statistically significant(χ^(2)=4.493,P=0.034).Con⁃clusion The application of edaravone combined with Xueshuantong injection in the treatment of acute cerebral infarc⁃tion can not only improve the clinical efficacy and alleviate the inflammatory reaction,but also improve the neurologi⁃cal function and effectively regulate the coagulation function,which is also conducive to the enhancement of the endo⁃thelial function of the blood vessels,and promotes the reduction of adverse reactions.