利多卡因硬膜外阻滞复合全麻对肺癌患者术后相关指标的影响作用分析

Analysis of the Effects of Lidocaine Epidural Block and General Anesthesia on Postoperative Indicators of Lung Cancer Patients

目的探讨给予肺癌患者利多卡因硬膜外阻滞复合全麻对其术后相关指标带来的影响。方法选取2021年4月—2022年11月于齐齐哈尔医学院附属第三医院行手术治疗的肺癌患者90例为研究对象,通过抽签法将其分成研究组和比较组,各45例。对全部患者应用异丙酚、芬太尼,并通过七氟烷辅助麻醉,再应用维库溴铵。研究组维持麻醉选用硬膜外注射利多卡因,比较组选用硬膜外注射氯化钠。对比两组麻醉效果、临床指标、应激指标、免疫功能、术后并发症。结果研究组术后VAS评分为(1.05±0.22)分低于比较组的(1.39±0.21)分,差异有统计学意义(t=7.499,P<0.001)。研究组临床指标优于比较组,差异有统计学意义(P<0.05)。术后,研究组应激指标优于比较组,差异有统计学意义(P<0.05)。术后,研究组免疫功能优于比较组,差异有统计学意义(P<0.05)。两组并发症发生率比较,差异无统计学意义(P>0.05)。结论给予肺癌患者利多卡因硬膜外阻滞复合全麻,不但可以提高麻醉效果,还能优化临床指标,也有利于应激指标和免疫功能的改善,并且不会导致术后并发症增加。

Objective To investigate the effects of lidocaine epidural block combined with general anesthesia on the postoperative indexes of lung cancer patients.Methods A total of 90 patients with lung cancer who underwent surgical treatment in the Third Affiliated Hospital of Qiqihar Medical College from April 2021 to November 2022 were se⁃lected as the study objects and divided into study group and comparison group by drawing lot,with 45 patients in each group.All patients were given propofol,fentanyl,sevoflurane assisted anesthesia,and vecuronium bromide.Epidural injection of lidocaine was used in the study group and epidural injection of sodium chloride was used in the compari⁃son group.Anesthesia effect,clinical indexes,stress indexes,immune function and postoperative complications were compared between the two groups.Results The VAS score of the study group(1.05±0.22)points was lower than that of the comparison group(1.39±0.21)points,and the difference was statistically significant(t=7.499,P<0.001).The clini⁃cal indexes of the study group were better than those of the comparison group,and the difference was statistically sig⁃nificant(P<0.05).After operation,the stress index of the study group were better than those of the comparison group,and the difference was statistically significant(P<0.05).After operation,the immune function of the study group were better than those of the comparison group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of complications between the two groups(P>0.05).Conclusion In lung cancer patients,lidocaine epidural block combined with general anesthesia can not only improve the anesthetic effect,but also optimize the clinical indicators,but also help to improve the stress indicators and immune function,and will not increase postoperative complications.