新生儿败血症NEU%、PCT、PLT的表达水平及临床指导意义

Expression levels and clinical significance of NEU%,PCT,PLT in neonatal sepsis

目的分析新生儿败血症中性粒细胞百分比(NEU%)、降钙素原(PCT)、血小板计数(PLT)的表达水平及临床指导意义。方法选取2020年1月至2022年10月宣城市人民医院收治的新生儿败血症患儿42例为观察组,另选取同期于本院生产且身体健康无感染的新生儿53名为对照组。对比两组NEU%、PCT、PLT水平,对比观察组不同病情严重程度、治疗前后NEU%、PCT、PLT水平;分析NEU%、PCT、PLT单一检测及三者联合检测在新生儿败血症的诊断价值。结果NEU%、PCT水平:观察组治疗前>对照组>观察组治疗后,差异有统计学意义(P<0.05);PLT水平:观察组治疗前<对照组<观察组治疗后,差异有统计学意义(P<0.05)。ROC结果显示,NEU%+PCT+PLT检测曲线下面积(AUC)为0.893,敏感度为0.934,特异度为0.904。结论新生儿败血症中NEU%、PCT水平升高,PLT水平下降,三指标均可作为新生儿败血症的诊断指标,且可提示新生儿败血症病情发展及治疗疗效,值得临床广泛应用。

Objective To analyze the expression levels and clinical significance of neutrophil percentage(NEU%),procalcitonin(PCT)and platelet count(PLT)in neonatal sepsis.Methods Forty-two neonates with sepsis admitted to Xuancheng People's Hospital from January 2020 to October 2022 were selected as the observation group,and 53 healthy neonates without infection during the same period were selected as the control group.The levels of NEU%,PCT and PLT in the two groups were compared.The levels of NEU%,PCT and PLT in the observation group were compared in different severity of disease,before and after treatment.The diagnostic value of NEU%,PCT and PLT in the diagnosis of neonatal sepsis was analyzed.Results NEU%,PCT level:the observation group before treatment>the control group>the observation group after treatment,the difference was statistically significant(P<0.05).PLT level:the observation group before treatment<the control group<the observation group after treatment,the difference was statistically significant(P<0.05).The levels of NEU%and PCT in the observation group before treatment were significantly higher than those after treatment,and the level of PLT in the observation group was lower than that after treatment,the difference was statistically significant(P<0.05).The ROC results showed that the area under curve(AUC)of NEU%+PCT+PLT detection was 0.893,the sensitivity was 0.934,and the specificity was 0.904.Conclusion In neonatal sepsis,NEU%,PCT levels increase,and PLT levels decrease.The three indicators can be used as diagnostic indicators for neonatal sepsis,and can prompt the development of neonatal sepsis and the curative effect of treatment,and are worthy of widespread clinical application.