摘要
The human gut is inhabited by numerous and diverse microbial communities,forming a complex and dynamic ecosystem that regulates digestion,absorption,metabolism,and immunization.However,host-microbe interactions are complex and not well understood due to the difficulty of accessing some sections of the intestinal tract in vivo.The divergence in interspecies and intestinal microbial composition between animal models and humans as well as the difficulty in inferring causation from metagenomic sequencing have promoted the development of the human-relevant in vitro ecosystem of the gut-microbiota communication.
作者
王慧
尤晓颜
赵国屏
Hui Wang;Xiao-Yan You;Guo-Ping Zhao(Master Lab for Innovative Application of Nature Products,National Center of Technology Innovation for Synthetic Biology,Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences(CAS),Tianjin 300308,China;Henan Engineering Research Center of Food Microbiology,College of Food and Bioengineering,Henan University of Science and Technology,Luoyang 471023,China;CAS-Key Laboratory of Synthetic Biology,CAS Center for Excellence in Molecular Plant Sciences,Shanghai Institute of Plant Physiology and Ecology,Chinese Academy of Sciences,Shanghai 200032,China;Engineering Laboratory for Nutrition,Shanghai Institute of Nutrition and Health,Chinese Academy of Sciences,Shanghai 200031,China;CAS Key Laboratory of Quantitative Engineering Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China)
基金
supported by the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Projects(TSBICIP-CXRC042)
the National Natural Science Foundation of China(31200035)
the China Postdoctoral Science Foundation(2022M713330)。
