金属基纳米材料介导的肿瘤化学动力学治疗研究进展

Research Progress in Tumor Chemodynamic Therapy Mediated by Metal-based Nanomaterials

化学动力疗法(chemodynamic therapy,CDT)是一种利用肿瘤微环境(tumor microenvironment,TME)弱酸、H_(2)O_(2)和GSH过量等特点,通过金属离子介导的芬顿或类芬顿反应,将内源性H_(2)O_(2)转化为高度细胞毒性的羟基自由基(·OH)来杀伤肿瘤细胞的方法.这种治疗方法因其侵袭性小、肿瘤特异性高而得到了广泛的研究,在肿瘤治疗方面显示出很好的治疗潜力.目前,已经开发了多种基于金属离子的纳米催化剂用于CDT,如Fe^(2+),Cu^(+),Mn^(2+),Ce^(3+)等.对这几种常见的金属基纳米催化剂在CDT中的应用进行了综述,并对CDT面临的挑战和未来的发展趋势进行了讨论.

Chemodynamic therapy(CDT)is a method to kill tumor cells by transforming endogenous H_(2)O_(2) into highly cytotoxic hydroxyl radicals(·OH)through metal ion-mediated Fenton or Fenton-like reactions,making use of the characteristics of excessive weak acid,H_(2)O_(2) and GSH in tumor microenvironment(TME).This treatment has been widely studied because of its low invasiveness and high tumor specificity,and has shown good therapeutic potential in tumor treatment.At present,a variety of metal ion-based nanocatalysts have been developed for CDT,such as Fe^(2+),Cu^(+),Mn^(2+),Ce^(3+)and so on.In this paper,the applications of these common metal-based nanocatalysts in CDT are reviewed,and the challenges and future development trends of CDT are discussed.