伽玛刀联合肝动脉栓塞化疗治疗原发性肝癌的疗效观察

Efficacy of Gamma Knife Combined with Hepatic Artery Embolization Chemotherapy in the Treatment of Primary Liver Cancer

目的:分析伽玛刀、肝动脉栓塞化疗联合手段治疗原发性肝癌的可行性。方法:选择2017年6月~2019年6月本院收治的90例原发性肝癌疾病患者,进行随机数字表法分组治疗。对照组患者采取肝动脉栓塞化疗治疗,观察组患者配合伽玛刀治疗,比较2组原发性肝癌疾病患者的治疗情况,包括近期疗效、不良反应、随访生存率情况以及治疗前后甲胎蛋白(Alpha Fetal Protein,AFP)水平。结果:组间近期疗效比较,观察组疾病控制率95.55%明显高于对照组的73.33%(P<0.05);组间肝区疼痛、低热、消化道症状等不良反应发生情况比较,2组发生率接近(P>0.05);组间患者随访1年生存率比较,观察组患者生存率73.33%高于对照组的44.44%(P<0.05);2组患者治疗后AFP水平较治疗前改善,且观察组(510.50±90.50)μg/mL优于对照组(740.50±105.50)μg/mL,差异有统计学意义(P<0.05)。结论:较肝动脉栓塞化疗单一治疗,伽玛刀+肝动脉栓塞化疗治疗原发性肝癌具有安全性、有效性,提升了患者的生存率,是有效联合治疗方法。

Objective:To analyze the feasibility of combined treatment of gamma knife and hepatic artery embolization chemotherapy for primary liver cancer.Methods:Select 90 patients with primary liver cancer who were admitted and treated in our hospital from June 2017 to June 2019,and were treated by random number table method.Patients in the control group were treated with hepatic artery embolization chemotherapy,patients in the observation group were treated with gamma knife,and the treatment status of the two groups of patients with primary liver cancer disease was compared,including the short-term efficacy,adverse reactions,follow-up survival rates,and alpha-fetoprotein before and after treatment(Alpha Fetal Protein,AFP)level.Results:In terms of the shortterm efficacy comparison between the groups,the disease control rate of the observation group was 95.55%significantly higher than that of the control group 73.33%(P<0.05);In terms of the incidence of adverse reactions such as liver pain,low fever,and gastrointestinal symptoms between the groups,the two groups The incidence was close to(P>0.05);Compared with the 1-year survival rate of patients between the groups,the survival rate of the observation group was 73.33%higher than that of the control group 44.44%(P<0.05);The AFP level of the two groups improved after treatment compared to before treatment,and the observation group(510.50±90.50)μg/mL is better than the control group(740.50±105.50)μg/mL(P<0.05).Conclusion:Comparing the single therapy of hepatic artery embolization chemotherapy,gamma knife+hepatic artery embolization chemotherapy for primary liver cancer has safety and effectiveness value,improves the survival rate of patients,and is an effective combined treatment method.