优化脉冲光、点阵CO_(2)激光联合复方肝素钠尿囊素凝胶透皮给药治疗儿童烧伤后增生性瘢痕

Optimized Pulsed Technology with Fractional CO_(2)Laser Combined and Compound Heparin Sodium and Allantoin Gel Transdermal Delivery in the Treatment of Hypertrophic Scar After Burns in Children

目的:探索优化脉冲光、点阵CO_(2)激光联合复方肝素钠尿囊素凝胶透皮给药治疗儿童烧伤后增生性瘢痕的临床疗效。方法:选择2020年1月-2021年6月在蚌埠市第三人民医院接受治疗的50例烧伤后增生性瘢痕患儿,按随机数字表法分为试验组(n=25)和对照组(n=25)。对照组采取优化脉冲光与点阵CO_(2)激光治疗,试验组采用优化脉冲光、点阵CO_(2)激光联合复方肝素钠尿囊素凝胶透皮给药治疗。两组各治疗3次,每次治疗间隔2个月,在治疗的不同阶段比较温哥华瘢痕量表(Vancouver scar scale,VSS)评分变化,不良反应发生率及患者满意度。结果:随治疗时间推移,所有患者VSS评分呈逐渐下降趋势。第3次治疗前及第3次治疗后3个月,试验组VSS评分均低于对照组(P<0.05);试验组不良反应发生率及患者满意度与对照组比较,差异均无统计学意义(P>0.05)。结论:优化脉冲光、点阵CO_(2)激光联合复方肝素钠尿囊素凝胶透皮给药治疗儿童烧伤后增生性瘢痕疗效确切,不良反应发生率较低,患者满意度较高。

Objective To explore the clinical efficacy of optimized pulsed technology with fractional CO_(2)laser combined compound heparin sodium and allantoin gel transdermal delivery in the treatment of hypertrophic scar after burns in children.Methods 50 cases of children patients with hypertrophic scar after burns in Bengbu Third People's Hospital,between January 2020 and June 2021were selected and divided into experimental group(n=25)and control group(n=25)according to the random number table method.The control group was given optimized pulsed technology combined with fractional CO_(2)laser,and the test group was treated with the combination of optimized pulsed technology,fractional CO_(2)laser and compound heparin sodium and allantoin gel transdermal delivery.The two groups were treated 3 times each,and the interval of each treatment was 2 months.The changes of vancouver scar scale(VSS)were compared at different stages of treatment,incidence of adverse reactions and patients satisfaction were compared between the two groups.Results The VSS scores of all patients showed a gradual downward trend with the treatment time.Before the third treatment and 3 months after the third treatment,the VSS scores of the experimental group were lower than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions and patient satisfaction between the experimental group and the control group(P>0.05).Conclusion The efficacy of optimized pulsed technology with fractional CO_(2)laser combined compound heparin sodium and allantoin gel transdermal delivery in the treatment of hypertrophic scar after burns in children is definite.The treatment can achieve a lower incidence of adverse reactions and a higher patients satisfaction.