赖氨葡锌联合四磨汤治疗小儿反复呼吸道感染的效果分析

Analysis of the effect of compound lysine hydrochloride and zinc gluconate combined with Simo Decoction in the treatment of recurrent respiratory tract infections in children

目的分析赖氨葡锌联合四磨汤治疗小儿反复呼吸道感染(RRTI)的临床疗效。方法80例RRTI患儿,按随机数字表法分为对照组和研究组,每组40例。对照组患儿采取赖氨葡锌进行治疗,研究组采取赖氨葡锌联合四磨汤进行治疗。比较两组患儿临床疗效、临床症状(喘息、发热、咳嗽)消失时间、炎症因子指标[白介素6(IL-6)、C反应蛋白(CRP)、降钙素原(PCT)]水平、不良反应(便秘、恶心、呕吐)发生情况。结果研究组患儿治疗总有效率95.00%高于对照组的77.50%,差异有统计学意义(P<0.05)。治疗后,研究组患儿喘息、发热、咳嗽消失时间分别为(3.74±0.92)、(2.12±0.25)、(3.11±0.88)d,短于对照组的(5.63±0.81)、(3.97±0.36)、(5.27±0.63)d,差异有统计学意义(P<0.05)。治疗后,研究组患儿IL-6(7.11±1.23)pg/ml、CRP(6.43±1.12)mg/L、PCT(0.16±0.04)ng/ml均低于对照组的(11.65±1.54)pg/ml、(10.96±2.83)mg/L、(0.41±0.12)ng/ml,差异具有统计学意义(P<0.05)。研究组患儿不良反应发生率10.00%与对照组的12.50%比较,差异无统计学意义(P>0.05)。结论赖氨葡锌联合四磨汤治疗小儿RRTI的效果较好,可改善患儿的炎症反应,缩短其临床症状改善的时间,且不增加不良反应,值得推广应用。

Objective To analyze the clinical efficacy of compound lysine hydrochloride and zinc gluconate combined with Simo Decoction in the treatment of recurrent respiratory tract infections(RRTI)in children.Methods A total of 80 children with RRTI were divided into control group and study group according to the random numerical table,with 40 cases in each group.The control group was treated with compound lysine hydrochloride and zinc gluconate,and the study group was treated with compound lysine hydrochloride and zinc gluconate and Simo Decoction.Both groups were compared in terms of clinical efficacy,time to disappearance of clinical symptoms(wheezing,fever,cough),levels of inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT)],and occurrence of adverse reactions(constipation,nausea,vomiting).Results The total effective rate of 95.00%in the study group was higher than that of 77.50%in the control group,and the difference was statistically significant(P<0.05).After treatment,the time to disappearance of wheezing,fever and cough were(3.74±0.92),(2.12±0.25)and(3.11±0.88)d in the study group,which was shorter than those of(5.63±0.81),(3.97±0.36)and(5.27±0.63)d in the control group,and the differences were statistically significant(P<0.05).After treatment,the study group had IL-6 of(7.11±1.23)pg/ml,CRP of(6.43±1.12)mg/L,and PCT of(0.16±0.04)ng/ml,which were lower than those of(11.65±1.54)pg/ml,(10.96±2.83)mg/L,and(0.41±0.12)ng/ml in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group was 10.00%,and the difference was not statistically significant when compared with that of 12.50%in the control group(P>0.05).Conclusion Compound lysine hydrochloride and zinc gluconate combined with Simo Decoction has a good effect on the treatment of RRTI in children,which can improve the inflammatory response of children,shorten the time of clinical symptoms improvement,and do not increase adverse reactions,so it is worth promoting and applying.