铁死亡在骨关节炎中的作用及治疗进展

The role and treatment progress of ferroptosis in osteoarthritis

骨关节炎是由复杂病因引起的以关节软骨非炎症性退行性变及关节边缘骨赘形成为特征的慢性关节炎性病变,其病理学复杂,发病机制尚不明确,最终可导致关节僵硬和功能活动障碍。目前针对骨关节炎的治疗局限于缓解症状和改善功能,并伴有不同程度的副作用。铁死亡是近年发现的一种新型程序性细胞死亡方式,与骨关节炎的病理生理过程相关,并且在骨关节炎的发生发展中发挥重要调控作用,其主要特征包括铁代谢失衡和活性氧蓄积。故以铁死亡为靶点的铁死亡抑制剂在骨关节炎的治疗中显现出了巨大的应用前景。在这篇综述中,笔者总结了铁死亡在骨关节炎发生发展中的相关机制,归纳了大量特异性治疗药物及其相应作用靶点,以期通过调节软骨细胞铁死亡来延缓和逆转骨关节炎的进展,具有一定的临床指导意义。

Osteoarthritis is a chronic inflammatory disease characterized by non inflammatory degeneration of articular cartilage and the formation of osteophytes at the edge of the joint,caused by complex causes.Its pathology is complex,and its pathogenesis is not yet clear,ultimately leading to joint stiffness and functional activity disorders.At present,the treatment for osteoarthritis is limited to alleviating symptoms and improving function,with varying degrees of side effects.Ferroptosis is a new type of programmed cell death discovered in recent years,which is related to the pathological and physiological processes of osteoarthritis and plays an important regulatory role in the occurrence and development of osteoarthritis.Its main characteristics include iron metabolism imbalance and accumulation of reactive oxygen species.Therefore,ferroptosis inhibitors targeting ferroptosis have shown great application prospects in the treatment of osteoarthritis.In this review,the author summarizes the relevant mechanisms of ferroptosis in the occurrence and development of osteoarthritis,outlines a large number of specific therapeutic drugs and their corresponding targets,with the aim of delaying and reversing the progression of osteoarthritis by regulating chondrocyte ferroptosis,which has certain clinical guiding significance.