基于线粒体质量控制系统失衡探究建中法治疗抑郁症的研究思路

Research Ideas on Treatment of Depression Based on Imbalance of Mitochondrial Quality Control System with Jianzhong Method

海马区线粒体功能障碍是抑郁症不断发展的主要原因。近年来,线粒体质量控制系统逐渐受到学界的重视,成为治疗抑郁症的新突破。其中,线粒体未折叠蛋白反应和线粒体自噬的串扰可能是抑郁症发病过程中的重要机制。建中法的代表方小建中汤具有温阳健脾的功效,常用于治疗脾虚型抑郁症。线粒体是小建中汤的重要作用靶点,这与“脾-线粒体”学说不谋而合。建中法可以改善机体脾虚状态,调控线粒体未折叠蛋白反应和线粒体自噬的水平,进而提升线粒体质量控制,改善线粒体功能,达到治疗抑郁症的作用。

Mitochondrial dysfunction in the hippocampus is the main cause of the continuous development of depression.In recent years,the mitochondrial quality control system has gradually received attention from the academic community and has become a new breakthrough in the treatment of depression.Among them,the crosstalk between mitochondrial unfolded protein response and mitochondrial autophagy may be important mechanisms in the pathogenesis of depression.The representative formula of Jianzhong method,namely,Xiaojianzhong Decoction,has the effect of warming yang and invigorating the spleen,and is commonly used to treat Spleen deficiency type depression.Mitochondria are important targets of Xiaojianzhong Decoction,which coincides with the"Spleen-mitochondria"theory.Jianzhong method can improve the Spleen deficiency state of the body,regulate the levels of mitochondrial unfolded protein response and mitochondrial autophagy,thereby enhancing mitochondrial quality control,improving mitochondrial function,and achieving the treatment of depression.