吲哚丙酸的理化特性及其调控动物肠道健康的研究进展

Research Progress of Physicochemical Property of Indole Propionic Acid and Its Regulation of Animal Intestinal Health

肠道菌群产生的多种代谢物在动物肠道健康和生理稳态调控方面具有重要作用。吲哚丙酸(IPA)是一种色氨酸经肠道细菌代谢产生的吲哚衍生物,具有抗氧化、抗炎和免疫调节作用,在代谢性和神经类疾病的预防和治疗方面受到广泛研究。近年来,一些研究指出IPA可通过调控肠道菌群结构、改善肠道屏障功能、增强肠道免疫对动物的肠道健康产生积极影响,并有望作为新型绿色饲用添加剂开发和应用。本文综述了IPA的理化特性、合成与代谢特点及其调控动物肠道健康的主要作用机制,旨在为IPA在动物肠道健康调控以及肠道疾病预防或治疗上的应用提供参考。

Intestinal bacteria produce a variety of metabolites that play an important role in the regulation of an⁃imal intestinal health and physiological homeostasis.Indole propionic acid(IPA)is an indole derivative derived from the bacterial metabolism of tryptophan in the gut,which has antioxidant,anti⁃inflammatory and immuno⁃modulatory effects,has been extensively researched in the prevention and treatment of metabolic and neurologi⁃cal diseases.Recently,several studies have reported that IPA has a positive effect on intestinal health by regula⁃ting the structure of intestinal bacteria,improving intestinal barrier function and enhancing intestinal immunity,and is expected to be developed and applied as a novel green feeding additive.This article reviews the physico⁃chemical property,synthetic and metabolic characteristics of IPA,as well as its main mechanisms of regulating animal intestinal health,to provide reference for the application of IPA in regulating animal intestinal health and preventing or treating intestinal diseases.