多胺在脂质代谢中的生理功能及作用机制

Physiological Function and Mechanism of Polyamines in Lipid Metabolism

多胺广泛存在于动植物细胞中,影响动植物机体糖代谢、脂质代谢和能量平衡,发挥重要的生理和生化功能。本文在广泛查阅国内外相关文献的基础上,对具有代表性的研究进行综述和分析,介绍了多胺的来源、含量测定、合成和代谢途径,系统总结了多胺在脂质代谢中的生理作用和多胺对脂质代谢的调节以及可能的信号通路,旨在为多胺的科学应用和治疗肥胖及其相关代谢疾病提供参考。

Polyamines are widely found in plant and animal cells.They affect the metabolism of sugar,lipid and energy,and play important physiological and biochemical functions.Based on extensive reference to rele⁃vant literature at home and abroad,this paper reviews and analyzes representative studies,introduces the source,content determination,synthesis and metabolic pathways of polyamines,systematically summarizes the physiological role of polyamines in lipid metabolism,the regulation of polyamines on lipid metabolism and the possible signaling pathways,to provide reference for the scientific application of polyamines and the treatment of obesity and related metabolic diseases.