核因子E2相关因子2在肾缺血-再灌注损伤中的作用

Effect of nuclear factor E2-related factor 2 on renal ischemia-reperfusion injury

肾缺血-再灌注损伤(RIRI)是导致急性肾损伤(AKI)最主要的原因,常见于外科手术、严重创伤、休克和药物性肾损伤中。目前仍然缺乏有效的治疗手段应对RIRI。氧化应激是RIRI主要的病理损伤机制,核因子E2相关因子2(Nrf2)是抗氧化应激反应的关键转录因子,可激活与氧化还原和解毒相关的各种细胞保护基因。近年来研究表明,Nrf2可通过调节氧化应激、炎症反应、细胞凋亡以及细胞自噬等途径,在RIRI的防治中发挥保护作用。因此,本文围绕Nrf2的结构及其生物学功能、Nrf2相关信号通路及Nrf2在RIRI发生发展中的作用及可能机制进行综述,以期为RIRI的预防和治疗提供新的思路。

Renal ischemia-reperfusion injury(RIRI)is the main cause of acute kidney injury(AKI),which commonly occurs in surgery,severe trauma,shock and drug-induced kidney injury.At present,effective treatment for RIRI is still lacking.Oxidative stress is the major pathological injury mechanism of RIRI.Nuclear factor E2-related factor 2(Nrf2)is the key transcription factor of anti-oxidative stress response,which may activate various cytoprotective genes related to redox and detoxification.Recent studies have shown that Nrf2 may play a protective role in the protection and treatment of RIRI by regulating oxidative stress,inflammation,cell apoptosis and autophagy,etc.Consequently,the structure and biological function of Nrf2,related signaling pathways,its role in the incidence and development of RIRI and potential mechanism were reviewed in this article,aiming to provide novel ideas for the prevention and treatment of RIRI.