壳聚糖微花对原花青素吸附机理的研究

Study on the Mechanism of Procyanidins Adsorption onto Chitosan Microflower

为了了解壳聚糖微花(chitosan microflower,CSMF)对原花青素(Procyanidins,PC)的吸附机理,以CSMF为吸附剂对不同吸附条件下的PC溶液进行吸附,并结合扫描电镜(SEM)、傅里叶红外(FTIR)、X-射线衍射(XRD)等对载药颗粒进行表征,并通过吸附动力学、吸附等温线和吸附热力学等方面对CSMF吸附PC的机理进行系统研究。结果表明,载药颗粒的FTIR图谱在1456 cm^(-1)处有产生一个新的特征峰,表明PC已成功负载到CSMF上。SEM和XRD分析结果表明负载后并不会改变CSMF的形貌和结晶度。吸附动力学表明,CSMF对PC的吸附符合准二级动力学模型,吸附速率受颗粒扩散和边界层扩散相互作用的影响。吸附等温线表明,Freundlich吸附等温线模型能更准确地反映了整个吸附过程,说明CSMF对PC的吸附过程是一种表面能不均匀性多层吸附。最后,吸附热力学表明,CSMF对PC的吸附是一个自发的熵减的物理吸附过程。

In order to understand the adsorption mechanism of chitosan microflower(CSMF)on procyanidins(PC),CSMF was used as an adsorbent to adsorb PC solutions under different adsorption conditions.The drug-loaded particles were characterized by scanning electron microscopy(SEM),Fourier infrared(FTIR),X-ray diffraction(XRD),etc.Through adsorption kinetics,adsorption isotherm,and adsorption thermodynamics,the mechanism of CSMF adsorption PC was systematically studied.The results showed that the FTIR pattern of the drug-loaded particles produced a new characteristic peak at 1456 cm^(-1),indicating that the PC was successfully loaded onto the CSMF.The results of SEM and XRD analysis showed that the morphology and crystallinity of CSMF did not change after loading.The adsorption kinetics showed that the adsorption of PC by CSMF conformed to the pseudo-second-order kinetic model,and the adsorption rate was affected by the interaction between particle diffusion and boundary layer diffusion.The adsorption isotherm showed that the Freundlich adsorption isotherm model could more accurately reflect the entire adsorption process,indicating that the adsorption process of CSMF to PC was multilayer adsorption with surface energy inhomogeneity.Finally,adsorption thermodynamics showed that the adsorption of PC by CSMF was a spontaneous physical adsorption process with reduced entropy.