疏肝解郁法治疗胃肠功能紊乱 合并焦虑、抑郁的研究进展

Research Progress in The Treatment of Gastrointestinal Dysfunction Combined with Anxiety and Depression by Soothing Liver and Resolving Depression

文章简述了胃肠功能紊乱与焦虑、抑郁并病的发病现状及病因病机,回顾目前临床治疗及实验研究的进展,分析表明胃肠功能紊乱合并焦虑、抑郁的治疗当重视肝脾,通过疏肝解郁可实现肝脾通调,常用药物包括越鞠丸、舒肝解郁胶囊等中成药及具有疏肝解郁功效的方剂,作用机制与调节5-HT、VIP、P物质、脑肠肽、NE、DA等多种神经递质有关。“脑—肠”轴、神经递质在疾病的发生发展中起到桥梁作用,可作为今后研究的关注方向。

The article briefly described the current situation,etiology and pathogenesis of gastrointestinal dysfunction,anxiety and depression,reviewed the current progress in clinical treatment and experimental research,and analyzed that the treatment of gastrointestinal dysfunction with anxiety and depression should pay attention to the liver and spleen,and the liver and spleen can be unblocked by relieving liver depression.Common drugs include Yueju Pill,Shugan Jieyu Capsule and other Chinese patent drugs,as well as prescriptions with the effect of relieving liver depression,the mechanism of action and regulation of 5-HT,VIP Substance P,brain gut peptide,NE,DA and other neurotransmitters.Brain gut axis and neurotransmitters play a bridge role in the occurrence and development of diseases,which can be the focus of future research.