溃疡性结肠炎患者粪便钙卫蛋白水平与病情严重程度的相关性研究

The Relativity of Ulcerative Colitis Patients' Fecal Colprotectin Levels and Their Condition Severity

目的:探讨溃疡性结肠炎(UC)患者粪便钙卫蛋白(FC)水平与病情严重程度的相关性。方法:将2021年4月至2022年10月我院收治的90例UC患者,按照Seo.m临床活动指数(CAI)分组,即CAI<150分为轻度组(21例),CAI 150~220分为中度组(35例),CAI>220分为重度组(34例)。比较3组患者FC水平及血液相关炎症指标C反应蛋白(CRP)、血清降钙素原(PCT)水平和中性粒细胞与淋巴细胞比例(NLR)。采用Spearman相关分析法分析FC、CRP、PCT、NLR与UC病情严重程度的相关性。建立受试者工作特征曲线(ROC),分析FC、CRP、PCT、NLR对重度UC的诊断价值。结果:3组患者FC及血清CRP、PCT、NLR比较差异显著,重度组明显高于中度组和轻度组(P<0.05);Spearman相关分析显示,FC及血清CRP、PCT、NLR与UC病情严重程度均呈正相关(P<0.05);曲线下面积(AUC)从大到小依次为FC 0.931(0.914~1.000)、NLR 0.843(0.772~0.887)、PCT 0.757(0.524~0.824)、CRP 0.736(0.565~0.832)。FC对于重度UC的AUC明显高于NLR、PCT、CRP(P<0.05)。当FC>167.26μg/g时,评估重度UC,其灵敏度为80.03%,特异度为93.53%。结论:FC水平与UC患者具有明显相关性,且FC>167.26 μg/g时评估重度UC的灵敏度和特异度明显高于其他血清炎症因子指标。

Objective To investigate the relativity of ulcerative colitis(UC) patients' fecal calprotectin(FC) levels and their condition severity. Methods According to CAI(Seo.m) divided 90 UC patients treated in authors' hospital(2021-04-2022-10) into slight group(21 cases, CAI150 points),moderate group(35 cases, CAI:150-220 points),and severe group(34 cases, CAI220 points);then, compared the levels of FC,as well as of CRP,PCT,more than, NLR between the three groups, further analysed the relativity of FC,CRP,PCT and NLR with UC condition severity by using Spearman relativity analysis method, established ROC so as to explore the diagnostic values of the four parameters on severe UC. Results Compared the FC,RPC,PCT,and NLR there were significant differences between the three groups, and, severe group, significantly higher than rest two groups(P<0.05);Spearman relativity analysis showed the four parameters were proportionally related to the severity(P<0.05);AUC in order(from large to small) were FC 0.931(0.914-1.000),NLR 0.843(0.772-0.887),PCT 0.757(0.524-0.824),and CRP 0.736(0.565-0.832),thus, FC's AUC was significantly higher than the AUC of NLR,PCT,and CRP(P<0.05);And, when FC167.26 μg/g, its sensitivity and specificity in evaluating severe UC were respectively 80.03% and 93.53%. Conclusion FC level has significant relativity to UC,when FC167.26 μg/g, its sensitivity and specificity in evaluating severe UC are significantly higher than that of other serum inflammatory factors.