肺癌患者血清纤维蛋白原、D-二聚体表达与临床病理特征的关系

Correlation of expressions of serum fibrinogen and D-dimer with clinicopathological features in patients with lung cancer

目的分析肺癌患者血清纤维蛋白原(FIB)、D-二聚体(D-D)的表达与临床病理特征的相关性。方法前瞻性研究。抽取2019年10月至2021年10月商丘市中心医院收治的肺癌患者80例,均于入院时检测血清FIB、D-D水平,观察并记录肺癌分期、远处转移等临床病理特征,分析血清FIB、D-D水平与肺癌患者临床病理特征的关系。结果肺癌Ⅲ~Ⅳ期和远处转移者血清FIB及D-D水平高于Ⅰ~Ⅱ期者及未远处转移者,差异有统计学意义(P<0.05);不同肿瘤长径、病理类型、肿瘤分化程度者血清FIB及D-D水平比较,差异未见统计学意义(P>0.05)。绘制受试者工作特征曲线结果显示,肺癌患者入院时血清FIB、D-D水平单项评估及联合评估预测TNM分期的曲线下面积(AUC)分别为0.715、0.784、0.816,均有一定的评估预测价值,且当血清FIB、D-D水平分别取4.065 g/L、1.960 mg/L时可获得最佳评估价值;肺癌患者入院时血清FIB、D-D水平单项评估及联合评估预测远处转移的AUC分别为0.733、0.782、0.809,均有一定评估预测价值,且当血清FIB、D-D水平分别取3.935 g/L、1.955 mg/L时可获得最佳评估价值。结论肺癌患者血清FIB、D-D水平与其临床病理特征中的肺癌分期、远处转移关系密切,临床可通过检测肺癌患者血清FIB、D-D水平,评估肺癌远处转移及临床分期。

Objective To analyze the correlation of expressions of serum fibrinogen(FIB)and D-dimer(D-D)with clinicopathological features of patients with lung cancer.Methods This was a prospective study.A total of 80 patients with lung cancer admitted to Central Hospital of Shangqiu from October 2019 to October 2021 were selected,and the levels of serum FIB and D-D were detected at the time of admission.The clinicopathological features,including lung cancer stage and distant metastasis,were observed and recorded,and the relationship of serum FIB and D-D with the clinicopathological features of patients with lung cancer was analyzed.Results The levels of serum FIB and D-D in patients with lung cancer stageⅢ-Ⅳwere higher than those in patients with lung cancer stageⅠ-Ⅱ,and levels of these indexes in patients with distant metastasis were higher than those in patients without distant metastasis(P<0.05).There was no significant difference in levels of serum FIB and D-D in patients with different tumor diameters,pathological types,and tumor differentiation degrees(P>0.05).The results of the receiver operating characteristic curve showed that area under the curve(AUC)of the single FIB,D-D,and combination of the two in lung cancer patients at admission in predicting tumor node and metastasis stage were 0.715,0.784,0.816,respectively.All of them had certain evaluation and prediction value.And the best evaluation value can be obtained when the levels of serum FIB and D-D were 4.065 g/L and 1.960 mg/L,respectively.The AUC of the single FIB,D-D,and combination of the two in predicting distant metastasis in patients with lung cancer were 0.733,0.782,and 0.809,indicating evaluative and predictive value,and the best evaluation value can be obtained when the serum FIB and D-D levels were 3.935 g/L and 1.955 mg/L,respectively.Conclusions The levels of serum FIB and D-D in patients with lung cancer are closely related to the cancer stage and distant metastasis.In clinical,the distant metastasis and clinical stage of lung cancer can be evaluated by detecting the levels of serum FIB and D-D in patients with lung cancer.