康莱特联合替吉奥同步放疗治疗老年食管癌的效果观察

Clinical effect of Kanglaite combined with tegafur concurrent radiotherapy on elderly patients with esophageal cancer

目的探讨康莱特联合替吉奥同步放疗治疗老年食管癌的效果。方法抽取2019年5月至2021年5月郑州人民医院收治的老年食管癌患者60例,按照双色球法分为对照组与观察组,每组30例。对照组采用替吉奥同步放疗,观察组采用康莱特联合替吉奥同步放疗。比较两组临床疗效、治疗前后血清肿瘤标志物[糖类抗原19-9(CA19-9)、糖类抗原125(CA125)、癌胚抗原(CEA)]水平及不良反应发生情况。结果观察组总有效率(93.33%,28/30)高于对照组(70.00%,21/30),差异有统计学意义(χ^(2)=6.24,P<0.05)。治疗前,两组肿瘤标志物水平比较差异未见统计学意义(P>0.05);治疗后,观察组CA125、CA19-9、CEA水平低于对照组(P<0.05)。两组肝脏毒性、肾脏毒性、皮肤反应发生率比较差异均未见统计学意义(P均>0.05),但观察组胃肠道反应、骨髓抑制、放射性肺炎发生率(10.00%,3/30;10.00%,3/30;6.67%,3/30)均低于对照组(33.33%,10/30;36.67%,11/30;26.67%,8/30),P均<0.05。随访1年时,观察组生存率(90.00%,27/30)高于对照组(60.00%,18/30),P<0.05。结论老年食管癌患者采取康莱特联合替吉奥同步放疗方案治疗,可以明显提高治疗效果,降低肿瘤标志物水平,减少不良反应发生,同时还可提高患者的远期生存率。

Objective To investigate the effect of Kanglaite combined with tegafur concurrent radiotherapy on elderly patients with esophageal cancer.Methods Sixty elderly patients with esophageal cancer who were treated in Zhengzhou People’s Hospital from May 2019 to May 2021 were selected,and they were divided into control group and observation group by the dichromatic-sphere method,with 30 cases in each group.The control group was treated by concurrent radiotherapy of tegafur,and the observation group was treated by concurrent radiotherapy of Kanglaite combined with tegafur.The clinical efficacy,preoperative and postoperative levels of serum tumor markers,including carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 125(CA125)and carcinoembryonic antigen(CEA),and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group(93.33%,28/30)was higher than that of the control group(70.00%,21/30),and the difference was significant(χ^(2)=6.24,P<0.05).Before treatment,there was no significant difference in levels of tumor markers between the two groups(P>0.05).After treatment,the levels of CA125,CA19-9 and CEA in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in the incidence of liver toxicity,kidney toxicity and skin reaction between the two groups(allP>0.05),however,the incidence of gastrointestinal reaction(10.00%,3/30),bone marrow suppression(10.00%,3/30)and radiation pneumonitis(6.67%,3/30)in the observation group were significantly lower than those in the control group(33.33%,10/30;36.67%,11/30;26.67%,8/30),and the differences were significant(allP<0.05).After 1 year of follow up,the survival rate of the observation group(90.00%,27/30)was higher than that of the control group(60.00%,18/30),P<0.05.Conclusions Kanglaite combined with tegafur concurrent radiotherapy,in the treatment of elderly patients with esophageal cancer,can significantly improve the clinical efficacy,reduce the levels of tumor markers,lower incidence of adverse reactions,and improve the long-term survival rate of patients.